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Micro-electrode arrays (MEAs) and micro-electrodes are used in a variety of medical applications for recording action potentials or stimulating neurons. To have an excellent signal-to-noise ratio, the contact between the neuronal tissue and the micro-electrodes must be very close. Therefore, a flexible MEA with a large number of.. Read More
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Flow Fields during Formation of W/O and O/W Emulsions using üPIV
The current work investigates two phase flow visualization in a micro channel using micron resolution particle image velocimetry (μPIV). Droplets of both oil-in-water and water-in-oil emulsions were generated in a T-shaped PDMS micro fluidic device and the corresponding flow fields were measured down-stream in the divergent s.. Read More
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Surface plasmon resonance (SPR) spectroscopy is a promising chip-based biosensor technology that can quantify various biomarkers without molecular labels or time-consuming sample preparation. The liSPR spectrometer is an inexpensive, convenient, portable, and robust SPR system. A drawback is that the chips’ sensing surface.. Read More
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Enzymatic Glucose Biofuel Cell and its Application
Biofuel cells have received significant attention in the last few decades due to its potential application as alternative energy sources and advantages over conventional fuel cells. This review summarizes different types of glucose biofuel cells with emphasis on enzymatic glucose biofuel cells. Unlike conventional fuel cells, wh.. Read More
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Osteogenesis is the cellular and molecular foundation of skeletal development and bone regeneration related to fracture healing, revitalization of bone graft and therapies for osteoporosis. A hallmark of osteogenesis is the mineralization of extracellular matrix. Because of its potential impact on developmental biology and hum.. Read More
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Current Applications of Tissue Engineering in Biomedicine
Tissue Engineering (TE) is a scientific field mainly focused on the development of tissue and organ substitutes by controlling biological, biophysical and/or biomechanical parameters in the laboratory. The result corresponds, in most cases, to the elaboration of three-dimensional cellular constructs with properties more similar .. Read More
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Quartz Crystal Microbalance in Cell Biology Studies
In the past two decades, quartz crystal microbalance (QCM) has evolved from a simple mass sensor to a powerful bioanalytical tool that is capable of assessing the properties of complex biological materials including cells. This evolution has led to the emergence of applications of the QCM in cell research that are potentially.. Read More
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Expression Profile of Angiogenesis Related Genes in Head and Neck Squamous Cell Carcinoma
Objectives: The molecular patterns of tumorigenesis of head and neck squamous cell carcinoma are mostly unknown to date. The concept of this investigation was to expose a genetic fingerprint of angiogenesis in HNSCC with special regard to VEGF as the outstanding mediator of neo-angiogenesis. Material and Methods: A panel .. Read More
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A multi-physics model is developed to predict the transient nonlinear behavior of electric-sensitive hydrogel membrane, based on a multi-phasic mixture theory. In the developed model involving chemo-electro-mechanics, the transient convection-diffusion equations for ionic concentrations incorporate the migration and diffusi.. Read More
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Spherical multicellular aggregate (spheroid) culture has attracted attention as useful technique for tissue engineering or regenerative medicine research and cell-based assay studies. Although spheroids are generated using floating culture method on non-adhesive surface, the transfer of floating spheroids to adherent culture hol.. Read More
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Glycosylphosphatidylinositol-Anchored Protein Chips for Patient-Tailored Multi-Parameter Proteomics
For the past two decades, highly multiplexed microarray-based assays have had a major impact on genomic studies, including DNA microarrays for the characterization of cellular states, phenotypic differences and disease markers. However, only recently similar technologies have become widely available for the analysis of the prote.. Read More
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Dental Cell Biology, Biochips and Open Access
Dental cell biology investigates the development and regeneration of dental tissues and biochips are therefore important tools in an advanced molecular research. Here, transcriptomics and proteomics are used for the evaluation of genome wide gene expression profiles of cultivated dental (stem) cells after various treatments or f.. Read More
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Microfluidic Biochips and Plastic-Antibody Biosensors for Point-of-Care Diagnostics
Microfluidic biochips have been studied since the 1990s. The research area continues to have an increase important role in biological fundamental research and medical diagnostics. In future, microfuidic biochips will continue to play a critical role in genomics, proteomics, and cellulomics, as evidenced by the increased demand f.. Read More
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Finally, A Routine Use for ES and iPS Cells
For more than a decade now the scientific community has been waiting for embryonic stem (ES) and induced pluripotent stem (iPS) cells to mature from an interesting research observation to a useful clinical tool. Unfortunately, it has become readily apparent that there are many barriers to clinical implementation for both ES and .. Read More
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What is the Value of Tissue Chips?
An increasing pressure, exerted on the one hand through ever increasing costs for the development of new drugs, and on the other hand by the public, that stipulates animal free research, has led to the development of more and more sophisticated in vitro test systems. Among them, special attention has to be turned on tissue chips.. Read More
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The Importance of Stem Cells and Bioengineering in Regenerative Medicine
The field of regenerative medicine is focused on the creation of functional human tissue to either model, repair or replace the damaged body part. This provides promise that in the future scientists will be able to bioengineer human tissue in vitro [1,2] that may allow the identification of novel medicines and has the potential .. Read More
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Analysing Displacement in the Posterior Mandible using Digital Image Correlation Method
Background: Knowing the biomechanical consequences of the stresses generated to the supporting bone during occlusal loading is significant for improving design and clinical planning process in partial edentualism therapy. The objective of this study was to analyze the surface displacement field on partial dentate mandible rehabi.. Read More
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Study on Slice-based Biosensor for Electrophysiological Propagation Measurement in Drugs Screening
In order to investigate the signal propagation of the cardiac tissue and the action of drugs, we developed a slice- based biosensor to monitor the electrophysiological activities of the cardiac tissues. At first, we analyzed the interface model of the slice-based biosensor and the electrolyte, and observed the characteristics o.. Read More
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Association of Genetic Variants of VEGF gene with Gastric Carcinoma Risk
To date, few association analyses with regard to gene variants and expression of vascular endothelial growth factor (VEGF) in gastric carcinoma (GC) have been reported. We hypothesized the variants might also affect susceptibility to GC. To evaluate the correlation of VEGF variants with risk and clinicopathological characteristi.. Read More
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Biochips: Bright Future in Clinical Dx?
Biochips play an established important role in research on disease biology and systems biology while an increasing number of clinical applications is emerging. What about the future of biochips in medical routine? The term biochip as used by us in this editorial is confined to chips in DNA/RNA analysis, just for sake of brevity,.. Read More
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