ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Commentary   
  • J Clin Exp Pathol 2015, Vol 6(1): 263
  • DOI: 10.4172/2161-0681.1000263

A Case of Exophytic Type 2A Papillary Renal Cell Carcinoma with Massive Necrosis

Toshihiro Magaribuchi1, Yasushi Adachi2,3, Naoto Kuroda4, Toru Sakatani1, Yoji Taki1, Ming Li3 and Susumu Ikehara3*
1Department of Urology, Toyooka Hospital, Toyooka City, Hyogo, Japan
2Department of Surgical Pathology, Toyooka Hospital, Japan
3Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka, Japan
4Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi City, Kochi, Japan
*Corresponding Author : Susumu Ikehara, Professor of Department of Stem Cell Disorders, Kansai Medical University, 2-5-1 Shinmachi, Hirakata City, Osaka 573-1010, Japan, Tel: 810728042450, Fax: 81-72-804-2454, Email: ikehara@hirakata.kmu.ac.jp

Received Date: Nov 13, 2015 / Accepted Date: Jan 01, 2016 / Published Date: Jan 04, 2016

Abstract

Most renal cell carcinomas (RCCs) are clear cell RCCs, the second most common being papillary RCCs (PRCCs). PRCCs are sub classified as type 1, type 2A, type 2B and mixed type. Pure type 2A PRCCs are estimated to account for only approximately 1-2% of malignant tumors of the kidney. In this paper, we show a case of an exophytic type 2A PRCC with massive necrosis arising in an 80-year-old male. The tumor, which measured 45mm in diameter and showed exophytic growth, was in the left kidney. The tumor was resected by a partial resection of the kidney and was found to be mainly necrotic, while the viable part showed papillary growth. There were small cuboidal cells with eosinophilic cytoplasm covering thin papillae with a single line of uniform small-to-medium sized nuclei and small nucleoli. The tumor was also positive for cytokeratin 7. Following Yang et al, we diagnosed the tumor as a type 2A PRCC.

Conclusion: Type 2 PRCCs should be clearly differentially diagnosed into type 2A or 2B, since the prognosis is different between these two types.

Keywords: Papillary renal cell carcinoma; Type 2A; Exophytic growth; Massive necrosis

Citation: Magaribuchi T, Adachi Y, Kuroda N, Sakatani T, Taki Y, et al. (2016) A Case of Exophytic Type 2A Papillary Renal Cell Carcinoma with Massive Necrosis. J Clin Exp Pathol 6:263. Doi: 10.4172/2161-0681.1000263

Copyright: © 2016 Magaribuchi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review summary

  1. Ikehara
    Posted on Jul 14 2016 at 11:44 pm
    The manuscript entitled '' A case of exophytic type 2A papillary renal cell carcinoma with massive necrosis" is well written and represents a very interesting case of renal cell carcinoma which added a new classification to the papillary renal cell carcinoma and is valid for publication. The authors should include an outline of the interest of reporting this case: learning points, histogenesis hypotheses, further directions for investigation.
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