ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol 2016, Vol 6(2): 268
  • DOI: 10.4172/2161-0681.1000268

Role of Nicotinic Acid in Mitigating Methomyl Induced Acute Toxicity in Albino Rats

Hashish EA and Elgaml SA*
Department of Clinical Pathology, Zagazig University, Zagazig, Sharkyia, Egypt
*Corresponding Author : Elgaml SA, Department of Clinical Pathology, Zagazig University, Zagazig, Egypt, Tel: 00201003551998, Fax: +20552283683, Email: drshimaa_68@yahoo.com

Received Date: Feb 27, 2016 / Accepted Date: Apr 13, 2016 / Published Date: Apr 17, 2016

Abstract

Methomyl has a significant animal and public health problem. The present study was designed to evaluate the protective effect of nicotinic acid against the acute toxic effects induced by methomyl in albino rats. Four groups were divided into control, nicotinic acid (NA) (100 mg/kg b.wt./twice daily) for 7 successive days, methomyl (MET) (8 mg/kg b.wt.) and nicotinic acid plus methomyl (NA+MET) treated groups. Red blood cells-RBCs count; hemoglobin- Hb, packed cell volume-PCV and blood indices were measured. Hepatic marker enzymes (aspartate aminotransferase-AST, alanine aminotransferase-ALT and alkaline phosphatase-ALP), proteinogram (total protein, albumin, globulin and albumin/ globulin ratio), serum bilirubin (total, direct and indirect) and serum urea and creatinine were measured. Acute MET toxicity resulted in normocytic normochromic anemia with a significant (P<0.05) increase in the AST, ALT and ALP activities. Serum protein and globulin were significantly (P<0.05) decreased with an increase in albumin globulin ratio (A/G ratio) in MET treated rats. Bilirubin (total and direct) and kidney markers were significantly (P<0.05) increased. The NA pretreatment showed an improvement in the erythrocytic parameters. It restored the hepatic and renal markers. This is the first study investigating the effects of NA supplementation on the hematological and biochemical parameters of methomyl intoxicated rats. These findings suggest that the nicotinic acid could be used in amelioration of the methomyl toxicity.

Keywords: Kidney; Liver; Methomyl, Nicotinic acid; Rats; Toxicity

Citation: Hashish EA, Elgaml SA (2016) Role of Nicotinic Acid in Mitigating Methomyl Induced Acute Toxicity in Albino Rats. J Clin Exp Pathol 6:268. Doi: 10.4172/2161-0681.1000268

Copyright: © 2016 Hashish EA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review summary

  1. Joseph M
    Posted on Jul 14 2016 at 11:47 pm
    In the present study, the authors present interesting evidence that the toxic effects of a major environmental hazard (methomyl-MET) can be ameliorated by pretreatment with nicotinic acid (NA). The pesticide analyzed in this study still remains a problem especially in suicidal attempts and occupational exposure cases. Details regarding calculation of lethal concentration of MET and the post treatment consequences of niacin need to be mentioned in the article.
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