ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • J Clin Exp Pathol 2016, Vol 6(5): 295
  • DOI: 10.4172/2161-0681.1000295

Prognostic Impact of Cancer Stem Cell-Like Phenotypes in Pancreatic Ductal Adenocarcinoma

Jin XH, Yamamoto K, Abe S, Onishi I, Kirimura S, Aihemaiti G, Kinowaki Y and Kitagawa M*
Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
*Corresponding Author : Kitagawa M, Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan, Tel: +81-3-5803-5173, Fax: +81-3-5803-0123, Email: masa.pth2@tmd.ac.jp

Received Date: Oct 13, 2016 / Accepted Date: Oct 18, 2016 / Published Date: Oct 20, 2016

Abstract

Aim: To investigate the expression of cancer stem cell-like phenotypes in invasive pancreatic ductal adenocarcinoma, we analysed the correlation between the expression status of stemness markers and minichromosome maintenance 2 (MCM2), and clinicopathological characteristics; we also evaluated the prognostic significance of cancer stem cell-like features. Methods and results: We performed immunohistochemical staining in 44 cases of invasive pancreatic ductal adenocarcinoma. Patients were classified into high-expression and low-expression groups on the basis of the expression level of CD133, CD44, ALDH1, EpCAM, and MCM2. Seventeen of the 44 cases (39%) demonstrated high expression levels of CD133, whereas 12 of the 44 cases (27%) demonstrated high expression levels of CD44; 36 of the 44 cases (81%) demonstrated high expression levels of ALDH1, and 21 of the 44 cases (47%) demonstrated high expression levels of EpCAM. MCM2 was expressed in the nuclei of cancer cells with a positive cell ratio that ranged from 10% to 70%. Frequent positive stemness markers and/or a low expression of MCM2 was significantly correlated with worse overall survival (P=0.030). We defined frequent positive stemness markers (number of highly expressed markers>3) and/or a low expression of MCM2 phenotypes as the representative pattern of a cancer stem cell-like phenotype. The cancer stem cell-like phenotype was identified as an independent factor of overall survival by univariate (P=0.03) and multivariate analysis (hazard ratio, 2.763%; 95% confidence interval, 1.121-6.813; P=0.0273). Conclusion: The cancer stem cell-like phenotype could be involved in therapeutic resistance, resulting in worse overall survival. The cancer stem cell-like phenotype can be an indicator of recurrence in cases of invasive pancreatic ductal adenocarcinoma.

Keywords: Pancreatic cancer; Invasive ductal adenocarcinoma; Immunohistochemistry; Prognosis; Cancer stem cell; MCM2

Citation: Jin XH, Yamamoto K, Abe S, Onishi I, Kirimura S, et al. (2016) Prognostic Impact of Cancer Stem Cell-Like Phenotypes in Pancreatic Ductal Adenocarcinoma. J Clin Exp Pathol 6:295. Doi: 10.4172/2161-0681.1000295

Copyright: © 2016 Jin XH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top