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Cancer Therapeutics Following Newton's Third Law
Cancer is a wound that never heals. This is suggested by the data produced after several years of cancer research and therapeutic interventions done worldwide. There is a strong similarity between Newton’s third law and therapeutic behavior of tumor. According to Newton’s third law “for every action, there is a.. Read More
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Cloning and Analysis of N-Acetyltransferase 9 Genes in Yellow Catfish Pelteobagrus fulvidraco
N-acetyltransferase 9 (NAT9) is an important reproduction-related gene in fish. In this study, we cloned the fulllength NAT9 cDNA sequence from yellow catfish Pelteobagrus fulvidraco. P. fulvidraco NAT9 cDNA is 1253 bp, which including non-coding region (584 bp) and open reading frame (669 bp). NAT9 gene encodes a 222 amino acid.. Read More
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Herba Swertiae Benefits the Gastrointestinal System In Vivo
Due to the increasing usage of herbal medicines and natural products for the body function management and ailments treatment and the lack of study on the beneficial effect of Herba Swertiae, a widely used traditional herbal medicine, this paper aimed to investigate the effect of Herba Swertiae on gastrointestinal system in vivo... Read More
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Radiotherapy has played a key role in the management of non–small-cell lung cancer (NSCLC). However, the use of radiotherapy in treating NSCLC is limited because of the intrinsic radiation resistance of tumor cells and injury to adjacent normal tissues. Many oncogenes are reported to be involved in radioresistance. Thus, n.. Read More
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Role of Regulatory T-cells in Oral Tolerance and Immunotherapy
Food allergies encompass a range of disorders ranging from being an inconvenience to even causing fatalities, mainly due to anaphylaxis. A large number of individuals are affected and this presents great health and economic implications. However as yet, apart from dietary avoidance, effective treatment strategies are practically.. Read More
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Both mannose-binding lectins (MBLs) and ficolins recognize and bind carbohydrates in pathogens and activate complement leading to opsonization, leukocyte activation, and direct pathogen clean. While MBLs have been reported in many fish species, the function of ficolins had not been identified in Pelteobagrus fulvidraco, despite .. Read More
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Common Pitfalls and Novel Opportunities for Predicting Variant Pathogenicity
The prediction of missense variant pathogenicity is normally performed using analyses of multiple sequence alignments optionally augmented with analyses of the (predicted) protein structure. The most straightforward way, though, is to search the literature to see whether this variant has already been described. Variant data from.. Read More
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In this research, the comparison study of intraorganelle nanoporation and ion uptake of osteoblast and tumor cells has been studied under the influences of specific programmable of picopulse generator and specific microchip. By using the MATLAB and COMSOL, the difference in responses of the normal and tumor cells for a given inp.. Read More
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In this manuscript, we report a novel, low cost and easy synthesis, iron-oxide nanoparticles were synthesized via room-temperature reduction of a mixture of ferric and ferrous salts, containing citric acid as capping agent. Next, anticancer drug doxorubicin (Dox) was used to form electrostatic conjugation with these nanoparticle.. Read More
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Influence of brassinosteroid correspondent viz. 24-epiBL and 28-homoBL were studied on morpho-physiological constraints of 10th DAS of Brassica oleracea viz. (cabbage, cauliflower and broccoli). Seed priming treatments with various concentrations of 24-epiBL and 28-homoBL (10–6 M, 10–9 M and 10–12 M) were appli.. Read More
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Phosphotransferases (kinases) use ATP as the universal phosphoryl donor whereas sulfotransferases use PAPS as the universal sulfuryl donor. Once phosphoryl group is transferred to a recipient molecule, it receives total of two negative charges changing its physicochemical properties. Similarly, upon sulfuryl transfer the recipie.. Read More
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In Vivo Safety of Aqueous Leaf Extract of Lippia javanica in Mice Models
Rural dwellers in Kenya often resort to herbal remedy and dietary control in the treatment of several diseases including diabetes mellitus (DM), hypertension, cancer and cardiac diseases. The therapeutic applications of such plants has largely rested upon their long-term clinical experience, however, their safety profiles has no.. Read More
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Experimental and Kinetic Studies on Acid Red 88 Dye (AR88) Adsorption by Azolla filiculoides
The use of Azolla filiculoides (AF) for the removal of Acid Red 88 dye (AR88) from aqueous solutions at different contact times, temperatures, pH, adsorbent doses and initial dye concentration was investigated. The extent of dye removal decreased with increasing adsorbent dosage and AR88 concentration, also increased with increa.. Read More
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Adiponectin is an adipocyte specific-secreted protein playing a major role in regulating insulin sensitivity and lipid metabolism. Peucedanum japonicum Thunb (PJT) grown on the cliff of Tokunoshima Island in Japan contains rich polyphenolic compounds and exerts hypolipidemic properties. In this study we studied the efficacy of P.. Read More
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Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis
The form of programmed cell death known as Apoptosis has become an intense focus of investigation in various fields including carcinogenesis and cancer therapy. It is a sequentially regulated suicidal programme where cells regulate certain enzymes including caspase 9 activation and cytochrome C release with apoptosis inducing fa.. Read More
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Outcomes after Bonebridge Implantation: Audiological Benefits and Health Related Quality of Life
Objective: Bone conduction implants (BCI) are medical devices for conductive and mixed hearing losses as well as for single side sensorineural deafness (SSD). All direct-drive BCI transmit vibrations directly to the skull bone and can be divided into percutaneous and active transcutaneous devices. Method: We report a case serie.. Read More
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Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase. We have investigated th.. Read More
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The effect of As (III) and As (V) was investigated in nutritionally important plant, Zea mays L. and the response on malondialdehyde (MDA) content, Glutathione, Protein, Chlorophyll A, Chlorophyll B, Carotenoids and the enzymatic antioxidants viz., superoxide dismutase (SOD), peroxidase (POD) and ascorbate peroxidase (APX) was f.. Read More
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Growth Performance of Domesticated Prunus africana Population in Muguga, Kiambu County, Kenya
Prunus africana (Hook. f.) is an evergreen tree that grows in African mountains. The species’ bark and bark extracts are used for the treatment of benign prostate hyperplasia. High demand for the bark and bark extracts has led to overexploitation of natural population of the species. P. africana is listed as an endangered .. Read More
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Changing Paradigms in Cell Biology: Their Implication and Possible Applications
The evolution of cell biology in the 20th century has evoked some remarkable changes in the existing paradigms. The discovery of alternative splicing, overlapping genes and protein splicing has shifted the one gene-one protein paradigm to several proteins. Proteins are no more the only catalytic macromolecule since the discovery.. Read More
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