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In the last few years, evidence has been mounting of the possible allosteric modulation of second messenger formation on β2-adrenoceptors (β2ARs) induced by non-arylethylamine compounds. We herein addressed this issue by carrying out functional and molecular modeling studies to explore the possibility that imidazole-co.. Read More
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Objective To observe the effects of lead acetate on body and kidney weight of Wistar albino rats and the protective role of EGb 761 on weight changes. 1.2 Methodology One hundred and twenty young male Wistar albino rats were randomly selected and divided into three groups, A, B and C, comprising of 40 animals. Each group was fur.. Read More
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Spectroscopic Studies of the Bis-3,6-Alkylamidoacridines as Potential Topoisomerase I Inhibitors
In this paper, the interaction of bis-3,6-alkylamidoacridines with calf thymus DNA (ctDNA) and their inhibitory effect on topoisomerase I are investigated. The binding mode of the low-molecular ligands to ctDNA was determined using UVvis absorption spectrophotometry, fluorescence spectrophotometry and circular dichroism. The bin.. Read More
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Aim: The present study was carried out to investigate hematological alterations induced after single intramuscular administration of long acting moxifloxacin at the dose rate of 7.5 mg/kg body weight in six healthy male sheep. Materials and methods: Blood samples were collected from treated animals from jugular vein into K2EDTA .. Read More
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Serum Calcium and Risk of Cardio Vascular Diseases with Menopause in North Indian Women
Menopause is a natural transition but has inconvenient effects on ageing women due to lack of health/ treatment awareness. Calcium supplements, which are commonly recommended to elderly people, particularly post menopausal women. Recent evidence warns that taking calcium supplements might increase myocardial infarction (MI) risk.. Read More
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Effects Of Menstrual Cycle On Sweating During Exercise Performed In Hot And Dry Environment
The aim of this study was to compare the local and global sweat rates between the follicular and luteal phases of ovulatory cycles during a progressive exercise until exhaustion, held in a warm and dry environment. Eight women found to be healthy after undergoing a physical examination and with regular, ovulatory menstrual cycle.. Read More
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Structure and Function of Protein
A host of micro and macromolecules are responsible for the proper functioning of a living cell. Among them, proteins are the most important and versatile macromolecules and carry out essentially all biological functions in the cells of living systems. Proteins present in the nasal fluid of vertebrates or in the sensillum lymph o.. Read More
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Fast Side-Chain Dynamics: Measurement, Analysis, and Their Role in Protein Function
Proteins are dynamic molecules that use coordinated atomic fluctuations to achieve proper function. These motions have fundamental implications for not only understanding how proteins function, but current methods of structure based drug design. In this review, we focus on providing an overview of the NMR experiments to detect s.. Read More
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A Comparison of 5P12-vMIP-II and vMIP-II as HIV-1 Entry Inhibitors
vMIP-II (viral macrophage inflammatory protein-II) is a chemokine analog expressed by human herpesvirus-8 that has the unique ability to bind multiple human chemokine receptors, including CCR5 and CXCR4, representative receptors of two major chemokine subfamilies. This broad binding ability gives vMIP-II powerful anti-inflammato.. Read More
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The Q module of the human mitochondrial Complex-I (NADH:ubiquinone oxidoreductase) comprises of four core protein subunits: NDUFS2, NDUFS3, NDUFS7 and NDUFS8. It is an intermediate unit, connecting the dehydrogenase domain (N module) and the membrane arm (P module) of the L shaped mitochondrial Complex-I. Its role is to transfer.. Read More
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Scytovirin Engineering Improves Carbohydrate Affinity and HIV-1 Entry Inhibition
Scytovirin, a cyanobacterium derived carbohydrate binding protein, acts as a potent HIV-1 entry inhibitor and could hold promise as a potential topical microbicide. Viral specificity is achieved as Scytovirin recognizes carbohydrate moieties rarely found in the extracellular matrix, but which are abundant on viral proteins. With.. Read More
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Solution and In silico Ligand Binding Studies of Cicer arietinum Lectin
The recombinant lectin from Cicer arietinum (rCAL) showed complex sugar specificity and could bind only the asialo triantennary glycan from Fetuin. The thermodynamic study of binding to this glycan indicated the process to be spontaneous and exothermic. The values obtained were, ΔG as -28.56 kJ mol-1; ΔH as -43.65 kJ m.. Read More
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Ribosomal Protein S1: An Important Trans-Translational Factor
S1 is an essential protein in Escherichia coli. Although not present in all bacteria, its importance for the initiation and elongation stages of protein synthesis is well established. Beside its roles as a ribosomal protein, S1 promotes transcriptional cycling, regulates bacteriophage T4 gene expression, forms a complex with the.. Read More
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The Induction of Pregnancy Block in Mice by Bodily Fluids via the Vomeronasal Organ
Animals have evolved specific communication systems to identify and attract mates, and to discern the social status of conspecifics. In mice, these exchanges of information involve the emission and detection of pheromones. These pheromones are detected by the vomeronasal system. While urine has long been identified as the primar.. Read More
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Aim: Ethanol intake decreases food intake in rat, and one of the possible mediators of this alcohol effect is leptin. On the other hand, the concentration of total plasma homocysteine is a well-established indicator for the risk of cardiovascular disease, and seems to be related to ethanol consumption. So, the aim of the present.. Read More
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Paraquat is a highly toxic and widely used herbicide with no antidote. Its toxicity in man and animals has been reported to cause severe acute and long term health problems which eventually could lead to death. Measurement of blood C-Reactive Protein level (CRP) serves as a useful screen for infections and inflammatory diseases... Read More
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In social insect, the perception of volatile molecules, odorants and releasing pheromones, is mediated via specialized olfactory organs is generally thought to be accomplished by odorant-binding proteins and pheromonecarrying proteins. These proteins play an important role in the solubilization, transport and deactivation of phe.. Read More
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Organisms must metabolize sulfur to survive. The amino acids cysteine and methionine contain sulfur, and essential biomolecules such as thiamine, lipoic acid, and glutathiones also require this element. The most abundant form of sulfur in nature is sulfate. Organisms utilize the sulfate reduction pathway to reduce sulfate to sul.. Read More
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Endophytic Yeast Rhodotorula rubra Strain TG-1: Antagonistic and Plant Protection Activities
Red yeast antagonist Rhodotorula rubra strain TG-1 was isolated from the tissue of sample rice plant in Uzbekistan. Strain TG-1 was transferred into plant vascular system by stem inoculation into rice plant. The antimicrobial activity of strain TG-1 against several pathogenic fungal and bacterial plant pathogens, including Fusar.. Read More
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Enzyme Inhibitors as Therapeutic Tools
The enzyme inhibition is valuable in the regulation of the enzyme activity. It has many applications, which include the drug design to target an enzyme. In the present review, we focus on the inhibition of different enzymes such as glycosidases, arylsulfatases and others by synthetic inhibitors or drugs. This provides the strate.. Read More
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