ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(2): 432
  • DOI: 10.4172/2161-0460.1000432

Correlation of Alzheimer’s Dementia Markers

Hossein Akhondi*
2880 N Tenaya Way, Suite 100, Las Vegas, NV 89128, Nevada, University of Nevada, USA
*Corresponding Author : Hossein Akhondi, Internal Medicine Associate Program Director, University of Nevada, 2880 N Tenaya Way, Suite 100, Las Vegas, NV 89128, Nevada, USA, Tel: 1-202-306-2370, Email: Hossein.Akhondiasl@hcahealthcare.com

Received Date: Mar 15, 2018 / Accepted Date: Mar 22, 2018 / Published Date: Mar 29, 2018

Abstract

Introduction: Alzheimer’s disease remains a major cause of morbidity, mortality and dependency in older patients with dementia. With increasing age in older population and dementia in western hemisphere, an inexpensive and unified modality for early diagnosis of AD is of utmost importance.
Methods: We sought to investigate single photon emission computed tomography (SPECT) imaging of the brain as a less expensive modality in a prospective single blinded study in a cohort with diagnosis of probable Alzheimer’s dementia. Patients’ demographics, family history, Mini Mental Status Exam, brain imaging, biomarkers such as Tau, Amyloid beta protein, and Apo E genotype were obtained and analyzed. We tested different possible correlations models for association of current diagnosis of Alzheimer’s disease with SPECT and biomarkers using Chi-square test.
Results: Biochemical markers (Amyloid beta 42 and tau protein) have higher sensitivity in identifying patients with AD. APOE genotype is less sensitive as a diagnostic test. SPECT did not correlate with biomarkers in early AD, but showed higher correlation in moderate and severe dementia. Further investigation is warranted to identify a more sensitive and specific yet inexpensive testing for early diagnosis of AD.
Discussion: Biochemical and genetic markers have a closer association with each other and with Alzheimer’s compared to their association with brain imaging of patients with Alzheimer’s disease.

Keywords: Alzheimer’s disease; SPECT scan; Tau protein; Aß42 protein; Apo E genotype; Mini mental status evaluation; Family history

Citation: Akhondi H (2018) Correlation of Alzheimer’s Dementia Markers. J Alzheimers Dis Parkinsonism 8: 432. Doi: 10.4172/2161-0460.1000432

Copyright: © 2018 Akhondi H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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