ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
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  • Research Article   
  • J Chem Biol Ther 2016, Vol 1(2): 111
  • DOI: 10.4172/2572-0406.1000111

Potential Anti-angiogenic Effect of a Combination of Boswellic Acids and Cisplatin against Chemically-induced Colon Cancer in Mice

Abdelaziz EZ1, Hegazy AMS2, Badawy A3, Bayomy NA4, Rabat AE5 and Fawzy MS6*
1Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Anatomy, Faculty of Medicine, Benha University, Egypt
3Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt
4Department of Histology, Faculty of Medicine, Tanta University, Egypt
5Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt
6Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
*Corresponding Author : Fawzy MS, Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt, Tel: 20 1008584720, Fax: (2) 064- 3216496, Email: manal2_khashana@ymail.com

Received Date: Jul 31, 2016 / Accepted Date: Sep 19, 2016 / Published Date: Sep 23, 2016

Abstract

Boswellic acids (BA) have been found to possess potent anti-inflammatory and anti-cancer activity. We aimed to explore the possible effect of BA as an adjuvant therapy with Cisplatin on chemically-induced colon cancer in mice. Colon cancer was induced in seventy healthy male albino mice using 1,2-dimethylhydrazine (DMH, 20 mg/kg/week, s.c.) for fifteen weeks. Treatment with BA, Cisplatin or both for another 3 weeks was applied. The mice were divided into seven groups: (i) Saline, (ii) DMH, (iii) Cisplatin, (iv-v): BA standardized extract (250 or 500 mg/kg) and (vi-vii): Cisplatin+BA (250 or 500 mg/kg), respectively. Serum interleukin-6, vascular endothelial growth factor and Cyclooxygenase 2 levels have been measured by ELISA assays. Immunohistochemical staining for CD31, in addition, was done. On examination of the colon tissue at the end of the therapeutic period, there was a significant decrease in the CD31 immunostaining score as a marker of tumor proliferation index and a significant decrease in measured serum markers in combination therapy treated group than Cisplatin monotherapy treated group. These results suggested that BA could augment the antitumor effects of Cisplatin. Hence, BA could be used as an adjuvant therapy in the clinical management of CRC after its validation in humans.

Keywords: Boswellic acids; CD31; Cisplatin; Colon cancer; COX-2; IL-6; VEGF

Citation: Abdelaziz EZ, Hegazy AMS, Badawy A, Bayomy NA, Rabat AE, et al. (2016) Potential Anti-angiogenic Effect of a Combination of Boswellic Acids and Cisplatin against Chemically-induced Colon Cancer in Mice. J Chem Biol Ther 2: 111. Doi: 10.4172/2572-0406.1000111

Copyright: © 2016 Abdelaziz EZ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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