Towards a Circuit-Level Understanding of Hippocampal CA1 Dysfunction in Alzheimer's Disease Across Anatomical Axes
Received Date: Dec 15, 2017 / Accepted Date: Jan 02, 2018 / Published Date: Jan 09, 2018
Abstract
The hippocampus has been a primary region of study with regards to synaptic and functional changes in Alzheimer’s disease (AD) due to its involvement in early stages, specifically area CA1. However, most work in this area has treated CA1 as a homogeneous structure comprised of uniform neural circuits. Yet, there is a plethora of evidence that CA1 varies in its structure and function across anatomical axes. Here I review the heterogeneity of the functional and circuit architecture of hippocampal area CA1 across three primary anatomical axes. I also summarize evidence that AD differentially affects these subregions, as well as hypotheses as to why this may occur.
Keywords: Alzheimer’s disease; Hippocampus; CA1; entorhinal cortex; Pyramidal neuron
Citation: Masurkar AV (2018) Towards a Circuit-Level Understanding of Hippocampal CA1 Dysfunction in Alzheimer’s Disease Across Anatomical Axes. J Alzheimers Dis Parkinsonism 8: 412. Doi: 10.4172/2161-0460.1000412
Copyright: ©2018 Masurkar AV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.