Abstract

Platelet-rich fibrin (PRF) is the second generation of platelet concentrates collected on a single fibrin matrix that contains various autologous cytokines and immune cells. PRF is extracted from plasma through centrifugation of autologous peripheral blood. Platelet concentrates can be used in alveolar socket to accelerate both soft and hard tissue healing by releasing growth factors. This systematic review aims to evaluate the efficacy of a local application of PRF on postoperative healing after an impacted mandibular third molar extraction. A comprehensive literature search using the advanced features of PubMed, Cochrane Library, and Scopus databases was carried out. 7 study articles accomplished the selection criteria and were included in this review. The results indicated that the local application of autologous PRF in the alveolar socket after impacted mandibular third molar extraction has a beneficial effect on postoperative outcomes. It significantly releases pain, reduces swelling. The increase of growth factors enhances bone healing. Unfortunately, no significant positive effect on postoperative trismus between PRF and control groups was observed in this review

Keywords: Bone healing; pain; Platelet-rich fibrin; Swelling; Tooth extraction