Journal of Molecular Pharmaceutics & Organic Process Research
Protein Protein interactions
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Protein–protein interactions (PPIs) are the process refers to intentional physical contacts that are established between two or more proteins complexes as a part of biochemical events and/or electrostatic forces, but they rarely act alone. The proteins are vital macromolecules, at both cellular and systemic levels. Protein–protein interactions are basic interactions to the structure and function of protein complexes.
The measurable effects of protein-protein interactions are: alter the kinetic properties of enzymes, which may be the result of subtle changes in substrate binding or allosteric effects; allow for substrate channeling by moving a substrate between domains or subunits, resulting ultimately in an intended end product; create a new binding site, typically for small effector molecules; inactivate or destroy a protein; change the specificity of a protein for its substrate through the interaction with different binding partners, e.g., demonstrate a new function that neither protein can exhibit alone; serve a regulatory role in either an upstream or a downstream event.
Sumru Savas No relationship betweenlipoprotein-associated phospholipase A2, proinflammatory cytokines, and neopterin Â in Alzheimer's disease PPT Version | PDF Version
Mapitsi S Thantsha In vitro antagonistic effects of Listeria adhesion protein (LAP)-expressing Lactobacillus casei against Listeria monocytogenes and Salmonella Typhimurium Copenhagen PPT Version | PDF Version
Yosef Yarden Classically, the 3âuntranslated region (3âUTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3âUTR alone, without all other elements in mRNA such as 5âUTR and coding region. The importance of independent 3âUTR RNA (referred as I3âUTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3âUTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3âUTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3âUTR were important for its tumor suppression activity. Then, the C/EBP 3âUTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3âUTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3âUTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990âs to 2000âs, world scientists found several 3âUTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3âUTR regions, although the existence of their transcribed products as independent 3âUTR RNAs is still to be confirmed. Our studies indicate that the independent 3âUTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole. PPT Version | PDF Version
Vladimir Sulimov âVladimir Sulimov-Dimonta-Ltd-and-Lomonosov-Moscow-State-University-Russia-Protein-ligand-low-energy-minima-pose-analysis-Docking-target-functions-evaluation-with-the-FLM-programâ PPT Version | PDF Version
Xingmin Sun A chimeric protein (mTcd138) comprising the glucosyltransferase and domains of toxin B and the receptor binding domain of toxin A provides full protection against Clostridium difficile infection in mice PPT Version | PDF Version
Joanna Trojanek Metalloproteinases and their inhibitors gene expression profiles in leukocytes of primary hypertension (PH), non-alcoholic fatty liver disease (NAFLD), and obese children PPT Version | PDF Version