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Tokyo Metropolitan Institute of Medical Science was established in April 2011 by the merge of three Tokyo metropolitan government-operated institutes, namely, Tokyo Metropolitan Institute for Neuroscience, Tokyo Institute of Psychiatry, and the Tokyo Metropolitan Institute of Medical Science. The ultimate goal of the institute is to improve the health and welfare of the citizens of the Tokyo city as well as those of our country through original discovery on the pathology and molecular basis of diseases and development of novel strategies for prediction, prevention, diagnosis and therapy of various diseases including mental disorders. The followings are the current research activities. Molecular and cellular mechanisms of regulation of neurological systems and diseases caused by their aberrancy. Molecular basis of psychiatric disorders and development of preventive and therapeutic strategies. Pathology and underlying mechanisms of various diseases including cancer, infectious diseases and metabolic syndrome and development of novel strategies for their diagnosis and treatment. Molecular mechanisms of cellular operation of proteins, genomes and other biomolecules responsible for maintenance of cellular homeostasis, stable inheritance of genome and its integrity, cellular defence against pathogens and stem cell regulation.
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