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Formulation, Characterization and Pharmacokinetic Evaluation of Telmisartan Solid Dispersions
Telmisartan (TEL), a BCS class II antihypertensive drug possesses poor aqueous solubility which results in poor bioavailability after oral administration. Solid dispersion approach has been widely and successfully used to improve the biopharmaceutical profiles of the poorly soluble drugs. Present study was an attempt to prepare .. Read More
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HER2-Targeted Antibody Treatment for Ovarian Cancer Future Opportunities
There are an estimated 240,000 new cases of ovarian cancer diagnosed worldwide each year. Due to late presentation, in many parts of the world it remains the most lethal gynecological cancer. In 2004, a new model description of this disease was proposed that combined both histopathological and molecular features and which classi.. Read More
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Molecular Chaperones and Co-chaperones as Therapeutic Targets for Cancer
Cancer is a devastating disease that has affected millions of people, consumed tremendous efforts in the treatment/care and is incurable. Statistics from www.seer.cancer.gov show 14,140,254 people were living with cancer in 2013 in US with 1,685,210 new cases projected and 595,690 estimated deaths to occur due to cancer in 2016... Read More
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Traditional Ayurvedic medicines: Pathway to develop anti-cancer drugs
Ayurveda, “life knowledge”, is an ancient Indian traditional medical system, which has been practiced for >5000 years and still in use with the same importance among many cultural tribes in Indian sub-continents. Ayurvedic medicine is a unique holistic approach to treatment where herbal medicines, special diets, y.. Read More
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The methylsulfonylmethane (MSM) is an organosulfur compound having sulfonyl functional group. It is occurred naturally in some primitive plants and used in disease related to chronic pain, inflammation, and arthritis. This study was attempted to evaluate the impact of biofield energy treatment on the physical, thermal, and spect.. Read More
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Characterization of Physical, Spectral and Thermal Properties of Biofield Treated 1,2,4-Triazole
Triazoles are an important class of compounds used as core molecule for the synthesis of many pharmaceutical drugs. The objective of the present research was to investigate the influence of biofield treatment on physical, spectral and thermal properties of 1,2,4-triazole. The study was performed in two groups, control and treatm.. Read More
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Structural and Physical Properties of Biofield Treated Thymol and Menthol
Thymol and menthol are naturally occurring plant derived compounds, which have excellent pharmaceutical and antimicrobial applications. The aim of this work was to evaluate the impact of biofield energy on physical and structural characteristics of thymol and menthol. The control and biofield treated compounds (thymol and mentho.. Read More
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Cellulose based polymers have shown tremendous potential as drug delivery carrier for oral drug delivery system (DDS). Hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC) are widely explored as excipients to improve the solubility of poorly water soluble drugs and to improve self-life of dosage form. This work is an a.. Read More
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A majority of Africans rely on traditional medicine as the primary form of health care. Yet most traditional medicine products have a short shelf life, especially for water-based formulations such as macerations, infusions and decoctions. Indeed, many of these water extracts become unfit for human consumption after five to seven.. Read More
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Excessive Intake Salt Contribution to Cognitive Impairment in Mice
Dementia mice model was prepared by D-gal, Morris water maze was used for behavior research; c(WB) method was used for the pre-dementia protein expression research. Results showed that excessive intake of salt significantly decreased the memory ability and significantly prolonged the escape time and distance to get the platform;.. Read More
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Objective: In view of the national key project for infectious diseases “the retreatment research of tuberculosis”, we determined the in vitro anti-mycobacterial activity of four drugs in the treatment, pasiniazid (Pa), moxifloxacin (Mfx), Rifabutin (Rfb) and rifapentini (Rft) in combination to multidrug-resistant and.. Read More
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Despite the introduction of Highly Active Antiretroviral Therapy (HAART), opportunistic skin diseases continue to be prevalent and persistent in human immunodeficiency virus-infected individuals. Patients in this study were already receiving antiretroviral therapy for more than 2 years presented clinically with skin malaise prev.. Read More
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Mucoadhesive formulations have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. This drug delivery system is suitable for drugs undergoing high first pass metabolism. It improves bioavailability, reduces dosing frequency and thereby minimizes the side effects and als.. Read More
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Vitex negundo and Murraya koenigii are popular Indian herbs which are used for various clinical disorders. The basic literature survey exposed that Vitex negundo hasantioxidant, antiulcer and anti-nociceptive activity and Murraya koenigii possessing anthelmintic, analgesic, cooling activity, but not many scientific studies have .. Read More
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Exhibiting fibrous and antimicrobial characteristics, Eichhornia crassipes (water hyacinth) presents an edge to be used in medicine. The study aims to provide a new source of multifilament surgical sutures from decorticated petiole fibers of water hyacinth. The fibers were braided and autoclaved for sterilization. After which, d.. Read More
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Cucurbita maxima (locally called pumpkin plant) are widely used in North West region of Cameroon as indigenous medicine and food for the management of anemia since time immemorial. The current study of this plant was undertaken to establish the effect of this plant on hematological parameters of albino rats and also to attempt t.. Read More
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Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology
Research has done to prepare Diclofenac Sodium quick dissolving tablets by Hole technology. Once these quick dissolving tablets contact with gastro enteric fluids, the fluid can enter the hole within the tablet and immediate breaking of the tablet goes to take place. This quick disintegration of tablets is additionally influence.. Read More
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In vitro Inhibition of Leishmania braziliensis Promastigotes Growth by a Fluconazole Microemulsion
Cutaneous leishmaniasis (CL) is the most prevalent form of the disease caused by the parasites Leishmania. However, effective topical treatments for the disease are lacking. Fluconazole (FLZ) is an antifungal agent that inhibits a key enzyme for the production of ergosterol, the main sterol in membranes of fungi and parasit.. Read More
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Evaluating the Photosensitivity of the Chinese Chlorella on Red Blood Cells
The photosensitivity of the Chinese Chlorella (CC) which is a natural algae is investigated by considering its ability of killing red blood cells when their mixture exposed to light. Different experimental studies were performed to figure out the photohemolysis rate of red blood cells mixed with different concentrations of the C.. Read More
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Role of Surfactants as Penetration Enhancer in Transdermal Drug Delivery System
Human skin is a remarkably efficient barrier, designed to keep ‘‘our insides in and the outsides out’’. This barrier property causes difficulties for transdermal delivery of therapeutic agents. One long-standing approach to increase the range of drugs that can be effectively delivered via this route has b.. Read More
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