Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +44 1223 790975


Failure of A andbeta; Removal to Improve Alzheimer's Dementia Opens the Door to New Thinking | OMICS International
ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Failure of A β Removal to Improve Alzheimer's Dementia Opens the Door to New Thinking

Perry EA, Perry G*, Castellani RJ and Moreira PI

College of Sciences, University of Texas at San Antonio, USA

Corresponding Author:
George Perry, Ph.D.
Dean and Professor, College of Sciences
University of Texas at San Antonio, USA
Tel: 210-458-4450
Fax: 210-458-4445

Received date: December 01, 2012; Accepted date: December 05, 2012; Published date: December 20, 2012

Citation: Perry EA, Perry G, Castellani RJ, Moreira PI (2012) Failure of Aß Removal to Improve Alzheimer’s Dementia Opens the Door to New Thinking. J Alzheimers Dis Parkinsonism 2:e126. doi:10.4172/2161-0460.1000e126

Copyright: © 2012 Perry EA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Alzheimers Disease & Parkinsonism

For the past century, Alzheimer (AD) and Parkinson disease (PD) research has focused on the abnormal filaments as hallmarks and later, on etiology of disease. This appealing path, removal of the abnormality, has been the therapeutic gateway for drug development for the past two decades. The most advanced approaches along the lines are the amyloid/tau vaccine and protease modulations to block fiber build up. Success in filament removal has been met, but patients have continued to suffer in a continuous slide of cognition. Numerous trials have confirmed that Aβ removal does not benefit sporadic AD patients whether applied early or late in the course of the disease. These findings clearly show Aβ removal has no benefits, yet instead of reassessing the hypothesis of pathology as causative, more trials are being initiated to remove Aβ prior to disease onset or in those where Aβ metabolism led to altered Aβ. While these new efforts could provide therapeutic benefit, failure of extensive testing to determine if Aβ is, in fact a critical protective response to aging could lead to increased dementia. Failure of Aβ removal to benefit patients is not being too early or too late, but rather working against the processes essential to maintaining normal function as we age, and who’s failure in AD lead to even greater Aβ deposition. Whether removal of tau or synuclein will meet similar fates remain to be tested. This is an exciting time in AD and PD research, a time when new opportunities will arise to understand how the brain maintains normal function as we age.

Post your comment

Share This Article

Article Usage

  • Total views: 12769
  • [From(publication date):
    December-2012 - May 31, 2023]
  • Breakdown by view type
  • HTML page views : 8467
  • PDF downloads : 4302