alexa Genetic and Metabolic Effects of Chemical Carcinogens: A Complex Interplay | OMICS International
ISSN: 2161-0681
Journal of Clinical & Experimental Pathology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Genetic and Metabolic Effects of Chemical Carcinogens: A Complex Interplay

Ruliang Xu*, Margaret Cho and Saul Harari

Department of Pathology, New York University Langone Medical Center, 550 First Avenue, New York, USA

*Corresponding Author:
Ruliang Xu
Department of Pathology
New York University Langone Medical Center
550 First Avenue, New York, NY10016, USA
Tel: 212 263 0728
Fax: 212 263 7916
E-mail: [email protected]

Received Date: March 26, 2013; Accepted Date: March 29, 2013; Published Date: April 01, 2013

Citation: Xu R, Cho M, Harari S (2013) Genetic and Metabolic Effects of Chemical Carcinogens: A Complex Interplay. J Clinic Experiment Pathol S2:e001. doi: 10.4172/2161-0681.S2-e001

Copyright: © 2013 Xu R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Clinical & Experimental Pathology

Exposure to chemicals, whether naturally occurring or industrially produced, is a constant and inescapable fact of life. While the vast majority of these chemical compounds are beneficial or completely harmless, a number of them are known to alter cellular genetics and metabolic activity leading to cancer development. Examples of such chemicals with an established causative relationship with human cancer include aflatoxins (found in food) and tobacco products [1].

Chemical-induced genetic and metabolic alterations are attributable to their deleterious effect on DNA repair, gene expression, activation of proto-oncogenes, and inhibition of tumor suppressor genes. Also, proteins and lipids that are normally responsible for maintenance of metabolic homeostasis, may be impaired by chemical carcinogens. These changes can result from the direct interaction of the chemicals with DNA, leading to double-strand DNA breakage, hindered repair of random DNA mutation or/and accumulation of bulky DNA adducts. Alternatively, a chemical carcinogen may deregulate the complex network of signaling pathways that is otherwise responsible for normal physiologic responses. These effects result in abnormal cellular DNA damage response and oxidative stress response [2].

Impaired cellular DNA damage is mediated primarily by two distinct kinase dependent pathways, namely the Ataxia Telangiectasia Mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR). Also, deregulation of the p53 or Mitogen Activated Kinase (MAPK) p38/MAPK-Activated Protein Kinase 2 (MK2) pathways can result in abnormal response to DNA damage. Oxidative stress, caused by Reactive Oxygen Species (ROS) such as hydrogen peroxide, superoxide and hydroxyl radicals can directly or indirectly cause DNA damage, affect free nucleotides, and denature proteins and lipids, eventually inducing mutagenesis and carcinogenesis [3]. ROS can be propagated by exposure to exogenous oxidative chemicals or by endogenous mitochondrial production during stress response. Chemical carcinogens can also activate NF-?B (nuclear transcriptional factor) inflammation associated pathways, stimulating the anti-apoptotic tumor promoting factors (i.e. STAT3) and pro-apoptotic tumor suppressor genes (i.e. p53, ARF) [4,5].

Damage can also be imparted by chemical carcinogens onto proteins and lipids, leading to genetic or epigenetic alterations. Many cancer-causing chemicals in humans must be metabolized by the cytochrome p450 system in order to become chemically/ biologically active. Once activated, these metabolites are able to interact with cellular macromolecules to induce misfolding/ unfolding of proteins and disruption of regulatory complexes such as the pro-apoptotic and heat shock response pathways.

It must be noted that the specific effect of chemical carcinogens on genetic integrity and metabolic pathways is largely dependent upon and modulated by a variety of factors. These include host susceptibility (age, race, gender, polymorphisms of carcinogen metabolism genes, etc.), dose and duration of chemical exposure, metabolic pathway, biotransformation, and interaction with myriad other environmental factors [6]. Thus, chemical carcinogenicity must be regarded as an end-product of a complex and multifactorial process involving the chemical, the host and other environmental factors.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Article Usage

  • Total views: 11882
  • [From(publication date):
    June-2013 - Jul 21, 2018]
  • Breakdown by view type
  • HTML page views : 8085
  • PDF downloads : 3797
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7