Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +1-947-333-4405


Mass Spectrometry Applications in Clinical Diagnostics | OMICS International
ISSN: 2161-0681
Journal of Clinical & Experimental Pathology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Mass Spectrometry Applications in Clinical Diagnostics

Qing H. Meng*

Clinical Chemistry, Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, USA

*Corresponding Author:
Qing H. Meng
Professor, Clinical Chemistry
Department of Laboratory Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX 77030, USA

Received Date: March 21, 2013; Accepted Date: March 23, 2013; Published Date: March 25, 2013

Citation: Meng QH (2013) Mass Spectrometry Applications in Clinical Diagnostics. J Clinic Experiment Pathol S6:e001. doi: 10.4172/2161-0681.S6-e001

Copyright: © 2013 Meng QH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Clinical & Experimental Pathology

Mass Spectrometry (MS) is an analytical technique used for determining the elemental composition of samples, quantifying the mass of particles and molecules, and elucidating the chemical structure of molecules. Various types of MS with high specificity, such as Liquid Chromatography (LC-MS), Gas Chromatography (GC-MS), and Matrix-Assisted Laser Desorption/Ionization/Time-Of-Flight (MALDI-TOF MS), are being increasingly valued and utilized as tools in clinical laboratories [1]. These MS techniques overcome the limitations of immunoassays and offer many advantages over earlier approaches.

Clinical laboratories use the MS technology for disease screening, diagnosis of disease and metabolic disorders, monitoring of drug therapy, identifying drug toxicity and poisoning, and discovering new biomarkers. Therapeutic monitoring of immunosuppressant drugs using MS is well established. Limitations of immunoassays such as nonspecific binding of the antibody and cross-reactivity with metabolites that often result in overestimation have made the more accurate LC/MS/MS methodologies the assays of choice [2]. LC/ MS/MS has become the standard for assay of steroid hormones for diagnosis of endocrine disorders. Vitamin D analysis by LC/MS/MS is widely used in the clinical laboratory today. Whereas immunoassays are unable to distinguish between 25-hydroxy vitamins D2 and D3, the LC/MS methodologies are able to measure these levels separately so the contribution of each to the total can be determined.

The capability of measuring thyroid hormones by tandem MS was developed recently and this has overcome the issues associated with immunoassays [3]. Triple quadrupole MS/MS is the preferred methodology for toxicology screening and for toxic drug quantitation [4]. In newborn and prenatal screening programs, electrospray tandem MS has made possible identification of inborn errors in metabolism or genetic defects so that preventive and medical intervention can be implemented promptly to relieve or treat the disease [5]. One of the new ways that MS technology is being used is in proteomics, for quantitative identification of small amounts of proteins or molecules in blood to serve as biomarkers. This has opened up the discovery of new tumor markers as a potentially promising area of application of MS [6]. The intensive research into metabolomics, the assessment of endogenous metabolites as new disease biomarkers, is another promising applications of MS, which has been demonstrated to be very well suited to discovery and clinical application of metabolite profiles [7]. Another area of increasing interest is the use of automated MALDI-TOF MS for rapid identification of microorganisms in clinical microbiology laboratories [8].

Yet, there are still challenges in the clinical application of this technology, including sample preparation, online extraction, throughput, automation, laboratory information system interfacing, inter-instruments standardization and harmonization, and FDA regulation. With emerging technologies in MS, we expect to see more robust and reliable MS applications with a broad menu of tests that will become routine diagnostic tools in clinical laboratories in the near future.


Post your comment

Share This Article

Article Usage

  • Total views: 17387
  • [From(publication date):
    June-2013 - Dec 05, 2023]
  • Breakdown by view type
  • HTML page views : 12534
  • PDF downloads : 4853