In Term Findings in Pregnencies with Normal Outcome of Placental Pathology
Received Date: Jan 02, 2021 / Accepted Date: Jan 16, 2021 / Published Date: Jan 22, 2021
Keywords: Amnionic fluid infection, Maternal vascular underperfusion, Fetal vascular underperfusion
In the evaluation of pregnancy complications, neglect of the placenta in developed countries has become a thing of the past. In 1997, the American College of Pathologists published guidelines for examining placentas in high-risk pregnancies; subsequently, the Perinatal Section of the Society for Pediatric Pathology within the us published a series of reports led by Redline et al. about the classification and reproducibility of the diagnosis of placental lesions. Such lesions were broadly categorized as those according to 1) amnionic fluid infection 2) maternal vascular underperfusion , and 3) fetal vascular underperfusion to which was added a fourth category-chronic placental inflammation During a workshop organized in Amsterdam in 2014, the recommendations for sampling and therefore the definitions of placental lesions were updated.
However, to date, there’s little or no information on how frequently histologic inflammatory or vascular lesions are found in placentas of patients with normal pregnancy outcomes, and this information is required to interpret the importance of placental histopathologic findings in patients who have obstetrical complications. Moreover, this information can also be useful in counselling patients about the result of the index pregnancy. The prognosis for subsequent pregnancies and during a medicolegal context. Often, the placenta has been considered a “witness” in litigation.
Therefore, the target of this study was to work out the frequency with which different pathological lesions are often detected histologically within the placenta during a large cohort of girls who had a singleton pregnancy, no obstetrical complications, and who delivered appropriate-for-gestational-age neonates at term without perinatal complications.
Placental Pathology Examination
Placentas were collected within the Labour and Delivery Unit or at Hutzel Women’s Hospital of the Detroit Center (DMC) and transferred to the Perinatology Research Branch (PRB) laboratory. For all placentas, the maternal surface (basal plate), fetal surface (chorionic plate), and therefore the duct were photographed before dissection. The gross morphologic description and placental measurements were documented, and therefore the placental weight was recorded before and after the trimming of the chorioamniotic membranes and duct. Sampling of the placentas was conducted consistent with protocols of the PRB and therefore the refore the Department of Pathology of the WSU School of drugs and the DMC.
Therefore, a study by researchers was conducted to work out the frequency with which different pathological lesions are often detected histologically within the placenta during a large cohort of girls who had a singleton pregnancy, no obstetrical complications, and that they delivered appropriate-for-gestational-age neonates at term without perinatal complications.
Researchers examined the collected Placentas from the Labor and Delivery Unit or OR at Hutzel Women’s Hospital of the Detroit Center (DMC) which were transferred to the Perinatology Research Branch (PRB) laboratory. All placentas, the maternal surface fetal surface (chorionic plate), and therefore the duct were photographed before dissection. The gross morphologic description and placental measurements were documented, and therefore the placental weight was recorded before and after the trimming of the chorioamniotic membranes and duct. Sampling of the placentas by researchers was conducted consistent with protocols of the PRB and therefore the refore the Department of Pathology of the WSU School of drugs and the DMC.
Finally Researchers report the frequency and sort of histologic lesions from an outsized series of placentas of girls with a traditional pregnancy outcome. Most placentas had some sort of lesion (either inflammatory or vascular), but most were mild. The results of their study are often used as a reference when interpreting the results of placental pathology in patients with perinatal complications. Placental histopathological lesions and therefore the extent to which they will cause obstetrical complications must be rigorously evaluated and quantified.
Current pathologic examination of the placenta relies on limited sampling of an outsized organ and taxonomy supported morphologic criteria that are largely qualitative. The appliance of advances in molecular pathology that address sampling [1-5], the identification of cellular markers of pathological processes, and therefore the computational methods utilized to summarize and analyse data are often utilized in placental pathology to enhance the characterization of this important organ.
- Budhraja V, Sadovsky Y (2006) Microarray analysis of trophoblast cells. Methods in molecular medicine 12: 411-424.
- Montenegro D, Romero R, Kim SS, Tarca AL, Draghici S, et al. (2009) Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition. J Pathol 217: 113-121.
- Szabo S, Xu Y, Romero R, Fule T, Karaszi K, et al. (2013) Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome. Virchows Archi 463: 445-458.
- Varkonyi T, Nagy B, Fule T, Tarca AL, Karaszi K, et al. (2011) Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similar. Placenta 32 Suppl S21-S29.
- Burton GJ, Sebire NJ, Myatt L, Tannetta D, Wang YL, et al. (2014) Optimising sample collection for placental research. Placenta 35: 9-22
Citation: Maitra A (2021) In Term Findings in Pregnencies with Normal Outcome of Placental Pathology. J Clin Exp Pathol 11: e127
Copyright: © 2021 Maitra A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
Open Access Journals
- Total views: 160
- [From(publication date): 0-0 - Feb 25, 2021]
- Breakdown by view type
- HTML page views: 137
- PDF downloads: 23