University of Texas at San Antonio, USA
Received Date: July 05, 2016; Accepted Date: July 06, 2016; Published Date: July 13, 2016
Citation: Perry G (2016) Management of Neuro Degenerative Diseases of Elderly Adults. J Alzheimers Dis Parkinsonism 6:e134. doi: 10.4172/2161-0460.1000e134
Copyright: © 2016 Perry G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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Alzheimer’s disease (AD) is a chronic neurodegenerative disease which includes challenges like language, disorientation, mood swings, behavioral issues, memory loss and lack of motivation. Pathogenesis of Alzheimer’s disease is poorly understood. Less than 5% of AD is believed to have genetic reasons with many genes involved. As the disease progresses bodily functions will be lost leading to death.
Parkinson’s disease (PD) is a disorder of the central nervous system affecting the motor system. Symptoms generally include rigidity, shaking, difficulty in walking, thinking & behavioral problems, depression, anxiety but dementia becomes common in the advanced stages. The cause for Parkinson’s disease is unknown, yet, genetic and environmental factors play a key role in the onset of the PD.
Journal of Alzheimer Disease & Parkinsonism is one of the best open access, Peer reviewed international journal that publishes scientific articles related to Alzheimer′s and Parkinson disease including its management, recent advances in their studies. The current volume no. 6, issue 3 accommodated eight high quality research articles, one case report, along with review and commentary articles.
Eggert et al. in their research article explored the possible risk of valvular heart disease (VHD) in patients with Parkinson’s disease (PD). Authors didn’t find any increased risk of cardiac VR in PD patients that is undergoing rotigotine or other non-ergot Dopamine agonists . Salah in the research article concluded that DNA polymerase is a viable therapeutic option for treating patients with multiple sclerosis .
Azza et al. studied the effect of Caffeine and nicotine on Alzheimers disease. Authors found that combined administration of caffeine and nicotine reduced the risk of neurodegenerative diseases, especially in the hippocampus by attenuating the impairment of learning and memory associated with AD . Fabregue et al. in their research found that interlukin (IL) IL-6/IL-10 ratio is the most appropriate marker to assess the level of inflammation during reaction time by which cognitive function can be assessed . Tong et al. in their studies found that T3D-959, a dual nuclear receptor agonist via agonism of PPAR delta and PPAR gamma nuclear receptors leads to modification of Alzheimer’s .
Kim et al. in their research article compared the effectiveness of three types of Trail Making Test (TMT) to identify the best and accurate ways of detecting the decline in cognitive skills among the Korean elderly patients. Authors found that TMT-B&W showed higher completion rate and found significant correlation with frontal executive function than other types of TMT tests . Ali et al. in their research article described the positive influence of Epigallocatechin-3-gallate and/or Coenzyme Q10 therapy for Alzheimer’s disease in rat models and Yang et al. studied the effects of Acetylation of PTEN on hepatic Gluconeogenesis [7,8].
Tang and Cheng in their mini review article briefly discussed about the effectiveness of chemical Trans differentiation in fighting neurodegenerative diseases . Masaoka and Philips  commented on the association of Sleep Disorder or Deficits in Olfaction with Neurodegeneration, leading to Dementia and the probable onset of Alzhemer’s disease among the elderly population of the Middle East. Kitamura and Hino reported a case of disinhibition associated with long-term use of donepezil in 88 and 98 year old women .
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