A Brief Review of Mast Cells in Microbial Infection (Inflammation) and Tumor-Associated Angiogenesis
Received Date: Jul 16, 2015 / Accepted Date: Jul 20, 2015 / Published Date: Jul 22, 2015
Mast cells are among cells of the immune system and participate in various physiological and protective immune functions in the body. Association of mast cells with allergic reactions and parasitic infections is well- documented. Various studies indicate that mast cells also play an important role in non-allergic phenomenon. Mast cells are reported to phagocytize and process antigens and play a protective role in immune response against bacterial infections. Mast cells not only act as the first line of defense against parasitic and bacterial infections but exert similar protective functions in viral infections through intracellular and extracellular antiviral defense mechanisms. Additionally, studies in human and animal neoplasms indicate that mast cells and several mast cell mediators are angiogenic, promote tumor-associated angiogenesis and facilitate progress of tumor malignancies and metastasis. This brief review gives a concise account of the role of mast cells in tumor angiogenesis and in microbial (bacteria and virus) infections.
Keywords: Bacteria; Infection; Mast cell; Tumor-angiogenesis; Virus
Citation: Woldemeskel M (2015) A Brief Review of Mast Cells in Microbial Infection (Inflammation) and Tumor-Associated Angiogenesis . J Clin Exp Pathol 5:e119. Doi: 10.4172/2161-0681.1000e119
Copyright: ©2015 Woldemeskel M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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