A Giant Primary Clear Cell Hepatocellular Carcinoma in a Young Woman without Cirrhosis
Received Date: Feb 18, 2015 / Accepted Date: Apr 21, 2015 / Published Date: Apr 28, 2015
Abstract
Primary clear cell carcinoma of the liver (PCCCL) is an uncommon variant of hepatocellular carcinoma, usually occurring in older patients with longstanding cirrhosis. We report a case of a giant PCCCL rupturing in a young woman without cirrhosis. A 29 year-old female who presented with a three month history of abdominal pain, nausea, vomiting, food intolerance, and unintentional weight loss, was found to have gastric varices and a large liver mass measuring 22.8cm × 17.8 cm × 13.8 cm. The tumor was comprised of sheets of clear cells with delicate vesicular architecture, and was positive for Hepar 1, Glypican 3, and CD34 in a diffuse staining pattern and CD10 in a canalicular staining pattern, establishing the diagnosis of PCCCL. The patient died of hemorrhagic shock secondary to tumor rupture within two weeks of diagnosis. Conclusion: Although PCCCL most often occurs in older patients with cirrhosis, this uncommon variant of HCC can arise in younger patients without a history of liver disease. It is important to diagnose PCCCL early due to the potentially favorable prognosis of this specific cancer and in order to prevent catastrophic complications.
Keywords: Clear cell hepatocellular carcinoma; Immunohistochemistry; Histology
Citation: ZH Ko J, Chen Y, Nepute J, Goodwill V, Garrett R, et al. (2015) A Giant Primary Clear Cell Hepatocellular Carcinoma in a Young Woman without Cirrhosis. J Clin Exp Pathol 5:224. Doi: 10.4172/2161-0681.1000224
Copyright: © 2015 Jeffrey ZH Ko, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Recommended Journals
Open Access Journals
Article Tools
Article Usage
- Total views: 15851
- [From(publication date): 6-2015 - Dec 11, 2024]
- Breakdown by view type
- HTML page views: 11372
- PDF downloads: 4479