A Systematic Review of the Association between Individual Drugs Injected Intravenously and the Development of Infective Endocarditis
Received Date: Nov 14, 2017 / Accepted Date: Nov 27, 2017 / Published Date: Dec 04, 2017
Issues: Infective endocarditis (IE) is a relatively rare disease that is associated with a significant amount of morbidity and mortality. Injection drug use associated IE is increasing in incidence, warranting a better understanding of how the drug of choice impacts the development of IE. Many studies have drawn connections between certain drugs injected intravenously and the development of IE but none have rigorously evaluated why a particular drug might predispose persons who inject drugs (PWID) to IE. Approach: The PubMed database was searched using a thorough search strategy. All human studies that reported on the drug(s) injected in patients who developed IE were analyzed and included.
Key findings: No specific drug convincingly showed a strong association between its intravenous use and the development of IE, with studies having contradicting findings. The array of findings reported in the reviewed studies are more likely to be due to the frequency of use of particular drugs and their availability in the respective regions of study than the actual physiologic or pharmacologic properties of the drug.
Implications: One trend that requires further investigation is the recent surge in opioid injection that has been linked to increased IE hospitalizations in several studies.
Conclusion: Future research should aim to better understand how the preparation and/or physical properties of specific drugs may play a role in the development of IE.
Keywords: Infective endocarditis; Intravenous drug abuse; Cocaine; Heroin; Opioids
Citation: Serhan J, Silverman MS (2017) A Systematic Review of the Association between Individual Drugs Injected Intravenously and the Development of Infective Endocarditis. J Addict Res Ther 8: 352. Doi: 10.4172/2155-6105.1000352
Copyright: © 2017 Serhan J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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