Abstract

Drug discovery is rapidly advancing across multiple fronts, enhancing our understanding and treatment capabilities for various diseases. Key progress areas include G protein-coupled receptors (GPCRs) and biased agonism, along with targeting protein-protein interactions. In oncology, developments in kinase inhibitors, RNA-based therapeutics, and epigenetic drugs are addressing cancer and drug resistance. Neuropharmacology is refining treatments for neurological disorders. Artificial Intelligence (AI) is revolutionizing the entire drug discovery process, while pharmacogenomics is personalizing medicine by matching therapies to genetic profiles, leading to safer and more effective interventions.