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An Association Study of the COMT and GABA Gene Variants with Alcohol Dependence | OMICS International| Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
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  • Research Article   
  • J Addict Res Ther 2017, Vol 8(6): 350
  • DOI: 10.4172/2155-6105.1000350

An Association Study of the COMT and GABA Gene Variants with Alcohol Dependence

Renu Singh1, Tripti Grover1, Ranjan Gupta1, Atul Ambekar2, Raka Jain2 and Arundhati Sharma1*
1Department of Anatomy, Laboratory of Cyto-Molecular Genetics, , AIIMS, New Delhi, India
2Department of Psychiatry, National Drug Dependence Treatment Center, , AIIMS, New Delhi, India
*Corresponding Author : Arundhati Sharma, Department of Anatomy, Laboratory of Cyto-Molecular Genetics, All India Institute Of Medical Sciences (AIIMS), New Delhi, India, Tel: 01126593489, Fax: 01126588626, Email: [email protected]

Received Date: Sep 29, 2017 / Accepted Date: Nov 05, 2017 / Published Date: Nov 12, 2017

Abstract

Alcohol dependence (AD), associated with high mortality and morbidity is caused due to involvement of both environmental and genetic factors. Behavioral effects of alcohol including cognitive impairment, motor incoordination, tolerance and dependence are likely due to its effect on the multiple brain proteins including neurotransmitters. Dysfunction in these neurotransmitter systems may be at the level of enzymes involved in metabolic degradation, or receptors involved in neurotransmission like dopamine, Gamma-amino butyric acid (GABA), serotonin etc. Genetic polymorphisms in these neurotransmitter systems are implicated in conferring susceptibility to AD.
Aim: To identify association of single nucleotide polymorphisms (SNPs) in COMT (rs4680 and rs2075507) and GABAA receptor genes (rs13172914 and rs211014) with AD. Method: A total of 100 AD patients diagnosed on the basis of DSM IV criteria from the outpatient clinic of the National Drug Dependence Treatment Centre (NDDTC) of All India Institute of Medical Sciences (AIIMS), and 100 healthy individuals from the general population were recruited. A detailed history including pattern of drug use and demographic details with pedigree information was noted. Genomic DNA from peripheral blood samples was processed for PCR amplification followed by restriction digestion to screen for the presence of polymorphisms. Genotype and allele frequencies were evaluated and correlated with alcohol use parameters including duration of alcohol use, age at onset of alcohol use, quantity of alcohol consumed (gms/day) and WHO ASSIST score and levels of liver function enzymes (SGPT and SGOT). Statistical analysis was performed using SPSS v21.0.
Results: Genetic analysis of the study group revealed COMT rs4680 to be significantly associated with AD (p=0.03), while the other COMT SNP rs2075507 showed an association with increased levels of SGPT in the patients. GABAA receptor gene polymorphisms showed no association with AD.
Conclusion: The study suggests a role of COMT gene polymorphism rs4680 in conferring susceptibility to AD.

Keywords: Alcohol dependence; Gene; Polymorphisms; GABAergic pathway; Dopaminergic pathway; COMT

Citation: Singh R, Grover T, Gupta R, Ambekar A, Jain R, et al. (2017) An Association Study of the COMT and GABA Gene Variants with Alcohol Dependence. J Addict Res Ther 8: 350. Doi: 10.4172/2155-6105.1000350

Copyright: ©2017 Singh R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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