ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Case Report   
  • J Clin Exp Pathol 2014, Vol 4(5): 192
  • DOI: 10.4172/2161-0681.1000192

An Unusual Cause of Central Diabetes Insipidus in a Young Female

Kush Dev Singh Jarial1, Abhishek Hajela1, Ashu Rastogi1, Kirti Gupta2, Louis Balan Gasper2, Anil Bhansali1, Pravin Salunke3 and Pinaki Dutta1*
1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
3Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India
*Corresponding Author : Dr. Pinaki Dutta, Assistant Professor, Department of Endocrinology, Nehru Hospital, Post Graduate Institute of Medical Education and Research, Chandigarh, India, Tel: 91-9357114777, Fax: 0172-2747944, Email: pinaki_dutta@hotmail.com

Received Date: Aug 26, 2014 / Accepted Date: Sep 24, 2014 / Published Date: Sep 27, 2014

Abstract

Central Diabetes Insipidus (CDI) in adults is most commonly occurs as a result of hypothalamo- pituitary surgery, head injury or various inflammatory and infiltrative disorders. CDI with mass lesions in the sellar-suprasellar area occurs due to infiltrative disorders like lymphoma, Langerhan’s cell histiocytosis, and inflammatory disorders like hypophysitis, mass lesions like germinoma, craniopharyngioma and even metastases. Treatment and correct diagnosis depends on histopathology. Rosai-Dorfman Disease (RDD) is a rare disorder of unknown etiology characterized by abnormal proliferation of histiocytes. Extra nodal involvement is found in 40-50% of cases; with Central nervous system (CNS) involvement being uncommon hence in majority of instances intracranial disease is not suspected. Due to paucity of the reported cases, optimal treatment options are not known. We report a young female who presented with CDI, hyperprolactinemia and other features of hypopituitarism along with systemic manifestations including nodal and skeletal involvement. The patient was treated with combination of surgical debulking followed by oral glucocorticoid for 6 months with gratifying results.

Keywords: Rosai?dorfman disease, Sellar-suprasellar mass, Diabetes insipidus

Citation: Jarial KDS, Hajela A, Rastogi A, Gupta K, Gasper LB, et al. (2014) An Unusual Cause of Central Diabetes Insipidus in a Young Female. J Clin Exp Pathol 4:192. Doi: 10.4172/2161-0681.1000192

Copyright: © 2014 Jarial KDS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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