alexa Anaplastic Lymphoma Kinase (ALK) Rearrangement and EGFR

Advances in Oncology Research and Treatments
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Anaplastic Lymphoma Kinase (ALK) Rearrangement and EGFR Mutations in Lung Adenocarcinoma

Emine Ikbal Atliine*, Cengiz Yakicier and Azra Akin

Faculty of Medicine, Trakya University, Turkey

*Corresponding Author:
Emine Ikbal Atliine
Faculty of Medicine
Trakya University, Edirne, Turkey
Tel: +90 284 236 4981
E-mail: [email protected]

Received Date: Mar 03, 2016; Accepted Date: Mar 24, 2016; Published Date: Mar 31, 2016

Citation: Atliine EI, Yakicier C, Akin A (2016) Anaplastic Lymphoma Kinase (ALK) Rearrangement and EGFR Mutations in Lung Adenocarcinoma. Adv Oncol Res Treat 1: 103. doi: 10.4172/2572-5025.1000103

Copyright: © 2016 Atliine EI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Purpose to objective: To establish the frequency of ALK translocation in lung cancer (adenocarcinomas) at Turkish adenocarcinoma patients level. Experimental design and methods: Between 2011- 2013, 157 paraffin embedded tumour tissues have been performed by our hospitals. 40 patients chosen from this group were also scanned for EGFR mutations. FISH technique is performed to paraffin embedded tissues were cut 4 micron thick. Vysis ALK Break apart FISH probe kit is used to detect rearrangement of ALK gene. 157 adenocarcinoma tumor tissue were analyzed. In 20 patients (12.7%) were found positive for ALK rearrangements. In our study ALK-positive and-negative patients, there is a difference between the 5.69 percent years. The results of ALK-positive patients compared to negative patients as a result showed that this group are younger patients. Conclusion: In summary, our study is the first study to investigate the ALK status in lung cancer in Turkish patients. Lung adenocarcinoma patients with ALK translocation, which has been reported to be younger age than carrying wild-type allele. According to result ALK breaks observed more frequently in patients at an early age. FISH analysis is the standard method for detecting ALK rearrangements. ALK gene rearrangements in patients with lung cancer, recent studies conducted on personalized treatment increases the success was observed. ALK gene rearrengements by FISH analysis has a leading role to Crizotinib treatment. Thus, wild type EGFR gene results and ALK gene rearrangements positive patients is related to increased survival after crizotinib treatment. Further studies about ALK gene is important to get more efficient cure result and figure out the molecular mechanism and structure

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords