Anti-Hu Antibody- and Anti-Zic4 Antibody-Positive Paraneoplastic Neurological Syndrome Presenting with Cerebellar Degeneration and Cranial Neuropathy: A Case Report
Received Date: Oct 06, 2022 / Accepted Date: Oct 20, 2022 / Published Date: Oct 27, 2021
Abstract
We present an illustrative case of a 62-year-old woman who developed progressive worsening of neurological symptoms with the simultaneous involvement of both peripheral and central nervous system. Our patient presented high titers of Anti-Hu and anti-Zic4 antibodies in her serum. We review the literature and found that multiple cranial palsies and concurrent cerebellar degeneration are uncommon in anti-Hu paraneoplastic syndromes. The patient was treated with intravenous immunoglobulin and methylprednisolone without significant improvement of symptoms.
Keywords: Cranial neuropathy, Cerebellar degeneration, Neurologic immune related adverse events, anti-Hu antibody, Paraneoplastic syndrome, case report
Citation: Kourtesis I, Orianou , Asteris Y, Georgatos G, Malteou M (2021) Anti-Hu Antibody- and Anti-Zic4 Antibody-Positive Paraneoplastic Neurological Syndrome Presenting with Cerebellar Degeneration and Cranial Neuropathy: A Case Report. J Clin Exp Neuroimmunol 6:134.
Copyright: © 2021 Kourtesis I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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