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Association of Resistin with BMI, Age, Diabetes and Breast Cancer Biomarkers | OMICS International| Abstract

Journal of Oncology Research and Treatment
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  • Research Article   
  • J Oncol Res Treat 2019, Vol 4(1): 135

Association of Resistin with BMI, Age, Diabetes and Breast Cancer Biomarkers

Rabindra Nath Das1,2* and Youngjo Lee2
1Department of Statistics, University of Burdwan, Burdwan, West Bengal, India
2Department of Statistics, College of Natural Science, Seoul National University, Seoul, Korea
*Corresponding Author : Rabindra Nath Das, Professor in Department of Statistics, University of Burdwan, Burdwan, West Bengal, 713104, India, Tel: +913422634975, Email: [email protected]

Received Date: Feb 04, 2019 / Accepted Date: Feb 19, 2019 / Published Date: Feb 25, 2019

Abstract

Breast cancer is the most often observed worldwide as the second cause of cancer-related death in women. High resistin level is associated with breast cancer, therefore it is considered as a breast cancer biomarker. For a real data set, the article shows that mean resistin is positively associated with monocyte chemoattractant protein-1 (MCP-1) (p<0.0001), types of patients (p<0.0001), interaction effect of Body Mass Index (BMI) and leptin (BMI*Leptin) (p=0.0415), Homeostasis Model Assessment Score (HOMA)*Age (p=0.1059), Adiponectin (p=0.1111), while it is negatively associated with HOMA (p=0.0698), Age (p=0.1249), Leptin*Adiponectin (p=0.0736), Glucose*Adiponectin (p=0.1007). Variance of resistin is positively associated with class of patients (p=0.0114) and BMI (p=0.0942). Some partially significant effects (around 15% level of significance) are included in the models treated as confounder according to Epidemiology. It is concluded that resistin is higher for younger women with breast cancer, higher levels of MCP-1, adiponectin, and higher interaction effects of BMI*Leptin, Age*HOMA.

Keywords: Adiponectin; BMI; Breast cancer; Leptin; MCP-1; Resistin; Non-constant variance 

Citation: Das RN, Lee Y (2019) Association of Resistin with BMI, Age, Diabetes and Breast Cancer Biomarkers. J Oncol Res Treat 4: 135.

Copyright: © 2019 Das RN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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