alexa Bacterial Etiologies of Fever in Sickle Cell Children followed up at Centre de Recherche et de Lutte Contre la Drepanocytose-Mali

Journal of Paediatric Laboratory Medicine
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Research Article

Bacterial Etiologies of Fever in Sickle Cell Children followed up at Centre de Recherche et de Lutte Contre la Drepanocytose-Mali

Mohamed Ag Baraïka1,2, Aldiouma Guindo1, Yeya dit Sadio Sarro1, Boubacari Ali Touré1, Abdoul Karim Dembélé1, Ibrahima Traoré1, Mariam Kanta1, Souleymane Diallo II3, Jean Bernard Lekana-Douki4,6 and Dapa Aly Diallo1,5*

1Centre for Sickle Cell Disease Research and Control (CRLD), Bamako, Mali

2Regional Doctoral School of Research in Tropical Infectiology (BDU), Franceville, Gabon

3Centre of Infectiology Charles Mérieux de Bamako (CICM), Bamako, Mali

4University of Evolution Epidemiology and Parasitic Resistance (UEEREP), Center International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon

5Department of Medical Hemato-Oncology, University Hospital of Point G, Bamako, Mali

6Department of Parasitology-Mycology Tropical Medicine, Faculty of Medicine, University of Health Sciences, Libreville, Gabon

*Corresponding Author:
Dapa Aly Diallo
Professor of Haematology
Faculty of Medicine and Odonto-Stomatology (FMOS)
University of Sciences
Techniques and Technologies of Bamako, Mali
Centre de Recherche et de Lutte contre la Drépanocytose (CRLD)
03 BP 186, Bamako, Mali
Tel: (00223) 20 22 38 98
Fax: (00223) 20 22 38 99
E-mail: [email protected], [email protected]

Received Date: November 11, 2016; Accepted Date: December 01, 2016; Published Date: December 05, 2016

Citation: Baraïka MA, Guindo A, Sarro YDS, Touré BA, Dembélé AK, et al. (2016) Bacterial Etiologies of Fever in Sickle Cell Children followed up at “Centre de Re-cherche et de Lutte Contre la Drépanocytose” – Mali. J Paediatr Lab Med 1:101.

Copyright: © 2016 Baraïka MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Fever is a common symptom in sickle cell patients, and may be a sign of a bacterial or non-bacterial infection.

Objective: Describe the bacterial aetiologies of fever in Sickle Cell Disease (SCD) children consulted or hospitalized, and the extent of confection with other pathogens in children at “Centre for Sickle Cell Disease Research and Control” (CRLD) in Bamako, Mali.

Patients and methods: From April 2014 to January 2016, a bacteriological study was conducted on nasal swabs, blood cultures, urine cultures and malaria diagnosis by Rapid Diagnosis Test (RDT) and Thick smear. All febrile SCD children aged 0.5-15 years seen at CRLD. All morbidity events related to fever were systematically recorded.

Results: Two hundred and thirty one SCD children were enrolled in this study. Urinary tract infections accounted for 14.28%; they were mainly caused by Escherichia coli, Klebsiella pneumonia, and Enterococcus faecalis. Blood cultures were positive for 10 patients (4.32%), and the isolated bacteria were dominated by Salmonella spp. Streptococcus pneumonia was the cause in 2 cases of pneumopathies confirmed by chest X-ray. Klebsiella pneumonia, isolated in naso-pharyngeal specimens, was the cause in a meningoencephalitis case which was gradually cured with antibiotic therapy. Fever was associated with malaria in 6.92% of the cases. Coinfections were frequent. Hospitalization was required for 62.3% of the children. Clinical progress was favourable in 99.2% of the cases; we noted 2 cases of death associated with HIV infection.

Conclusion: Fever in sickle-cell children in Mali is frequently associated with a urinary or invasive infection due to enterobacteria other than Salmonella. However, malaria and viral infections also play a key role in its occurrence, as well as coinfections. This study calls for exploration of immunological characteristics that contribute to the occurrence of bacterial infections in sickle cell children.

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