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Bevacizumab (Bmab)+Dihydropyrimidine Dehydrogenase (DPD) Inhibitory Fluoropyrimidine (DIF) Combined Chemotherapy for the Treatment of Late-Stage Elderly Patients with Advanced/Recurent Colorectal Cancer (ARCC)| Abstract

Journal of Oncology Research and Treatment
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  • Research Article   
  • J Oncol Res Treat 2018, Vol 3(1): 119

Bevacizumab (Bmab)+Dihydropyrimidine Dehydrogenase (DPD) Inhibitory Fluoropyrimidine (DIF) Combined Chemotherapy for the Treatment of Late-Stage Elderly Patients with Advanced/Recurent Colorectal Cancer (ARCC)

Kazuma Kobayashi*, Fumihiko Fujita, Yusuke Inoue, Chika Sakimura, Sayaka Kuba, Taiiichiro Kosaka, Taiiichiro Kosaka, Kosho Yamanouchi, Kengo Kanetaka, Tamotsu Kuroki and Susumu Eguchi
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
*Corresponding Author : Kazuma Kobayashi, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan, Tel: 95-819-7316, Fax: 95-819-7319, Email: [email protected]

Received Date: Dec 18, 2017 / Accepted Date: Jan 25, 2018 / Published Date: Feb 02, 2018

Abstract

Purpose: In Japan, elderly people account for more than 20% of the total population. The incidence of elderly patients with advanced/recurrent colorectal cancer (ARCC) has also been increasing. However, the optimal regimen for elderly patients, especially those older than 75 years of age (late-stage elderly), has not been established. This study aims to examine the optimal chemotherapeutic regimens for late-stage elderly patients, and focuses on combined chemotherapy with Bevacizumab (Bmab)+dihydropyrimidine (DPD) dehydrogenase inhibitory fluoropyrimidine (DIF).

Methods: Between January 1996 and October 2014, 30 late-stage elderly chemotherapy-naïve patients with ARCC (male/female=16/14; average age, 79.1 years) were retrospectively reviewed. The treatment regimens were: Bmab+DIF (n=11) and other regimens (n=19).

Results: The MST was 979 days, the median PFS was 350 days and the RR was 23.3%. The grade ≥3 AEs with each of the regimens were as follows: Bmab+DIF, 1.9%, other regimens, 14.4%. Although no significant differences were observed in the OS or PFS between Bmab+DIF and the other regimens, the rate of transition to a 2nd-line chemotherapy after disease progression following first-line treatment was higher with Bmab+DIF (54.6% [6/11]) than with the other regimens (38.9% [7/18]); however, this difference did not reach statistical significance.

Conclusions: It is possible to prolong survival through chemotherapy in both late-stage elderly patients and younger patients with ARCC. Although the only appropriate specific regimen was not confirmed, given that it was associated with a 100% disease control rate, good feasibility and smooth transition to 2nd-line chemotherapy, Bmab+DIF was suggested to be a candidate treatment for late-stage elderly patients with ARCC.

Keywords: Elderly patient; Colorectal cancer; Bevacizumab; DIF

Citation: Kobayashi K, Fujita F, Inoue Y, Sakimura C, Kuba S, et al. (2018) Bevacizumab (Bmab)+Dihydropyrimidine Dehydrogenase (DPD) Inhibitory Fluoropyrimidine (DIF) Combined Chemotherapy for the Treatment of Late-Stage Elderly Patients with Advanced/Recurent Colorectal Cancer (ARCC). J Oncol Res Treat 3: 119.

Copyright: © 2018 Kobayashi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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