alexa Blastoid Mantle Cell Variant of Richterandrsquo;s Transformation | OMICS International| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Case Report   
  • J Clin Exp Pathol, Vol 9(1): 365
  • DOI: 10.4172/2161-0681.1000365

Blastoid Mantle Cell Variant of Richter’s Transformation

John G Prichard1*, Wayne W Chen2, Mrugesh C Shah3, Dayana E Tobar4 and Edmund H Wong5
1Department of Hematology and Oncology, Ventura County Medical Center, USA
2Neogenomics Laboratories, 31 Columbia Aliso Viejo, California, USA
3Department of Pathology, Ventura County Medical Center, USA
4Department of Hematology and Oncology, Ventura County Medical Center, USA
5Palms Imaging Center, 1901 Outlet Center Drive, California, USA
*Corresponding Author : John G Prichard, Department of Hematology and Oncology, Ventura County Medical Center, 300 Hillmont, Building 340, Ventura, California 93003, USA, Tel: 1(805)6526524, Email: [email protected]

Received Date: Mar 18, 2019 / Accepted Date: Mar 25, 2019 / Published Date: Mar 30, 2019

Abstract

An unusual occurrence of blastoid variant of mantle cell lymphoma arising in a patient with untreated chronic lymphocytic leukemia/small lymphocytic lymphoma is described. A localized site of intense uptake on positron emission tomography suggested Richter's transformation. Biopsy of the suspect area showed the blastoid variant of mantle cell lymphoma. Immunohistochemistry and fluorescence in situ hybridization confirmed the identity of both tumors. Molecular studies established that the mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma were clonally related.

Keywords: Chronic lymphocytic leukemia; Richter transformation; Mantle cell lymphoma; Blastoid variant mantle cell lymphoma; Positron emission tomography

Citation: Prichard JG, Chen WW, Shah MC, Tobar DE, Wong EH (2019) Blastoid Mantle Cell Variant of Richter's Transformation. J Clin Exp Pathol 9: 365. Doi: 10.4172/2161-0681.1000365

Copyright: © 2019 Prichard JG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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