Abstract

This collection of reviews highlights significant progress in pediatric hematology-oncology. Advancements span improved diagnostics,
therapeutic strategies, and supportive care for various conditions, including leukemias, lymphomas, and solid tumors. Key
breakthroughs include hydroxyurea for sickle cell anemia, gene therapy for hemophilia A, and CAR T-cells for acute lymphoblastic
leukemia. Allogeneic HSCT outcomes have improved for non-malignant disorders, while therapies for immune thrombocytopenia,
severe aplastic anemia, thalassemia, myelodysplastic syndromes, and Langerhans cell histiocytosis are continually refined, aiming
to enhance survival and quality of life for pediatric patients.