Abstract

Breast cancer is the most common malignancy in women worldwide and is a major cause of morbidity and mortality. A significant proportion of breast cancer patients develop metastasis to the bone, which is associated with poor prognosis and reduced survival rates. Understanding the mechanisms underlying breast cancer bone metastasis is crucial for developing effective therapeutic strategies. The bone microenvironment plays a pivotal role in the initiation, progression, and maintenance of bone metastases. This review focuses on the interaction between breast cancer cells and the endosteal niche within the bone microenvironment, highlighting key molecular and cellular players involved in the process of bone metastasis. Additionally, we discuss current therapeutic approaches and potential future directions for targeting the endosteal niche in the treatment of breast cancer bone metastasis.