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  • Research Article   
  • J Clin Exp Pathol 2012, Vol 2(7): 131
  • DOI: 10.4172/2161-0681.1000131

Candidaemia in Immune-Compromised Hosts: Incidence and Drugs Susceptibility

Maria T. Mascellino*, Giammarco Raponi, Alessandra Oliva, Claudio M. Mastroianni and Vincenzo Vullo
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy
*Corresponding Author : Maria T. Mascellino, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy, Tel: +39- 3281685935, Fax: +39- 0649972628, Email: [email protected]

Received Date: Sep 21, 2012 / Accepted Date: Oct 17, 2012 / Published Date: Oct 20, 2012

Abstract

Abstract
We analyzed the different Candidae species isolated from bloodstream infections and the related antifungal
susceptibility pattern over a five-year period (2007-2011) at Policlinico Umberto I of Rome (Italy).
The overall incidence of candidaemia during this range of time accounted for 6.4% with a marked increase from
2007 to 2011 (from 3.83% to 9%). The species isolated were the following: C. albicans (42%) and non-albicans (58%).
In the period 2007-2009, C.krusei was the most frequent species detected among non-albicans species (29.4%),
followed by C.glabrata (20%), whereas during 2010-2011 we found a shift versus C. parapsilosis increasing from 4.6%
to 33%.
C.albicans showed a good susceptibility to the most antifungal agents. C. krusei exhibited a raising resistance to
flucytosin and fluconazole. As for fluconazole, it shows an intrinsic resistance. In C. glabrata we observed increased
resistance especially to fluconazole for which this species shows a Susceptibility Dose-Dependent (SDD). C.tropicalis
had only a resistance to fluconazole (MIC 90%=16 mcg/ml) In vitro activity of the echinocandins resulted to be very
strong for all Candidae species. These drugs have a fungicidal activity and their use is recommended in the most
severe diseases.
Our study confirms the high incidence of candidaemia in the setting of critically ill patients. A strong association of
Candidae infection with the presence of Central Venous Catheter (CVC) has been markedly noticed especially in the
years 2009 and 2011 due to a greater use of CVC in our patients. The overall rate of resistance increased over the
study period in all Candidae strains.

Keywords: C. albicans and non-albicans; Candidaemie; Antimycotic agents susceptibility; Azoles; Echinocandins; Central Venous Catheter (CVC)

Citation: Mascellino MT, Raponi G, Oliva A, Mastroianni CM, Vullo V (2012) Candidaemia in Immune-Compromised Hosts: Incidence and Drugs Susceptibility. J Clin Exp Pathol 2:131. Doi: 10.4172/2161-0681.1000131

Copyright: © 2012 Mascellino MT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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