Case Report: High-Sensitivity C-Reactive Protein is a Potentially Useful Marker of the Need for Psychotic Treatment for Cognitive Dysfunction Related to Low-Grade Inflammation
Received Date: Sep 08, 2017 / Accepted Date: Nov 17, 2017 / Published Date: Nov 24, 2017
We encountered a 79 year old female patient with mild cognitive impairment who showed sustained improvement to an almost normal level of global cognitive function for >1 year when treated with donepezil. Her levels of high-sensitivity C-reactive protein (hs-CRP) also showed a sustained decrease with treatment. Here, we describe the clinical changes in her cognition and discuss the relationship between cognitive function and low-grade inflammation, focusing on three important issues. First, cognitive dysfunction may be related to low-grade inflammation. Second, hs-CRP may be a suitable marker for this low-grade inflammation. Third, treatment with cholinesterase inhibitors was effective, either by suppressing this low-grade inflammation or by upregulating acetylcholine, which suppresses such inflammation. In this patient, inflammation appeared to be related to the cholinergic anti-inflammatory pathway.
Keywords: Acetylcholine; Cholinergic anti-inflammatory pathway; High sensitive C-reactive protein; Low grade inflammation; Pseudodementia
Citation: Hori K, Konishi K, Hosoi M, Sodenaga M, Kamatani H, et al. (2017) Case Report: High-Sensitivity C-Reactive Protein is a Potentially Useful Marker of the Need for Psychotic Treatment for Cognitive Dysfunction Related to Low- Grade Inflammation. J Alzheimers Dis Parkinsonism 7: 402. Doi: 10.4172/2161-0460.1000402
Copyright: © 2017 Hori K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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