alexa Case Report: High-Sensitivity C-Reactive Protein is a Potentially Useful Marker of the Need for Psychotic Treatment for Cognitive Dysfunction Related to Low-Grade Inflammation| Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Case Report   
  • J Alzheimers Dis Parkinsonism 2017, Vol 7(6): 402
  • DOI: 10.4172/2161-0460.1000402

Case Report: High-Sensitivity C-Reactive Protein is a Potentially Useful Marker of the Need for Psychotic Treatment for Cognitive Dysfunction Related to Low-Grade Inflammation

Koji Hori1,2*, Kimiko Konishi1,3, Misa Hosoi2, Michiho Sodenaga1, Hiroyuki Kamatani4, Hiroi Tomioka2 and Mitsugu Hachisu5
1Department of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan
2Department of Psychiatry, Showa University, Northern Yokohama Hospital, Yokohama, Yokohama, Japan
3Tokyo Metropolitan Tobu Medical Center for Persons with Developmental/ Multiple Disabilities, , Tokyo, Japan
4Department of Psychiatry, Kawasaki Memorial Hospital, , Kawasaki, Japan
5Division of Clinical Pharmacy, Department of Pharmaceutical Therapeutics, School of Pharmacy, Showa University, Tokyo, Japan
*Corresponding Author : Koji Hori, Department of Neuropsychiatry, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamaeku, Kawasaki City Kanagawa, Japan, Tel: +81-44-977-8111, Fax: +81-44-976-3341, Email: [email protected]

Received Date: Sep 08, 2017 / Accepted Date: Nov 17, 2017 / Published Date: Nov 24, 2017

Abstract

We encountered a 79 year old female patient with mild cognitive impairment who showed sustained improvement to an almost normal level of global cognitive function for >1 year when treated with donepezil. Her levels of high-sensitivity C-reactive protein (hs-CRP) also showed a sustained decrease with treatment. Here, we describe the clinical changes in her cognition and discuss the relationship between cognitive function and low-grade inflammation, focusing on three important issues. First, cognitive dysfunction may be related to low-grade inflammation. Second, hs-CRP may be a suitable marker for this low-grade inflammation. Third, treatment with cholinesterase inhibitors was effective, either by suppressing this low-grade inflammation or by upregulating acetylcholine, which suppresses such inflammation. In this patient, inflammation appeared to be related to the cholinergic anti-inflammatory pathway.

Keywords: Acetylcholine; Cholinergic anti-inflammatory pathway; High sensitive C-reactive protein; Low grade inflammation; Pseudodementia

Citation: Hori K, Konishi K, Hosoi M, Sodenaga M, Kamatani H, et al. (2017) Case Report: High-Sensitivity C-Reactive Protein is a Potentially Useful Marker of the Need for Psychotic Treatment for Cognitive Dysfunction Related to Low- Grade Inflammation. J Alzheimers Dis Parkinsonism 7: 402. Doi: 10.4172/2161-0460.1000402

Copyright: © 2017 Hori K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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