alexa Center Role of the Oxytocin-Secreting System in Neuroendocrine-ImmuneNetwork Revisited

Journal of Clinical & Experimental Neuroimmunology
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Review Article

Center Role of the Oxytocin-Secreting System in Neuroendocrine-ImmuneNetwork Revisited

Yu-Feng Wang*

Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150086, PR China

*Corresponding Author:
Yu-Feng Wang
Department of Physiology, School of Basic Medical Sciences
Harbin Medical University, Harbin 150086, PR China
Tel: +86-451-86674538
Fax: +86-451-86674538
E-mail: [email protected]

Received Date: December 06, 2015; Accepted Date: February 11, 2016; Published Date: February 15, 2016

Citation: Wang (2016) Center Role of the Oxytocin-Secreting System in Neuroendocrine-Immune Network Revisited. J Clin Exp Neuroimmunol 1:102. doi: 10.4172/jceni.1000102

Copyright: © 2016 Wang YF. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The hypothalamic neuroendocrine system has extensive and bidirectional interactions with immune system. In parallel with the hypothalamic-pituitary-adrenal axis, the oxytocin-secreting system composed of hypothalamic oxytocin neurons and their associated neural tissues has also emerged as a major part of the neuroendocrine center that regulates immunologic activities of living organisms. This oxytocin neuron-immune network can synthesize and release many cytokines and oxytocin while being the target of both oxytocin and cytokines by the mediation of corresponding receptors. Pathogens and cytokines along with the humoral and neural activities induced by them provide afferent input onto oxytocin neurons while oxytocin, cytokines and autonomic nervous systems convey efferent signals from the oxytocin-secreting system to the immune system. Serving as an integrative organelle, the oxytocin-secreting system coordinates all neural, humoral and immunologic signals to change immunologic activities through releasing oxytocin into the brain and blood to minimize pathological injury and secure the functional stability of our body. Oxytocin exerts these effects through strengthening surface barriers and maintaining immunologic homeostasis involving both humoral immunity and cellular immunity. In this review, we revisit the novel concept: the oxytocin-secreting system is the center structure in the oxytocin neuron-immune network.


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