Abstract

This compilation explores the profound comorbidity between chronic pain and mental health disorders like depression, anxiety, and PTSD. It highlights shared neurobiological pathways, emphasizing how these conditions mutually influence each other. The data reveals chronic pain’s significant impact on mental health outcomes, worsening function and increasing suicidality risk. Integrated, multidisciplinary treatment strategies, combining physical, psychological, and pharmacological approaches, including Acceptance and Commitment Therapy (ACT), are crucial for effective management. A holistic approach, comprehensive screening, and targeted psychological support are essential for optimal patient care and improved quality of life.