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ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Case Report

Circadian Rhythm in Stroke: The Influence of Our Internal Cellular Clock on Cerebrovascular Events

Nils Schallner1-3, Robert LeBlanc III1, Leo E Otterbein2 and Khalid A Hanafy1,4*

1Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA

2Department of Surgery, Beth Israel Deaconess Medical Center, Transplant Institute, USA

3Department of Anesthesiology and Critical Care Medicine, University Medical Center, 79106 Freiburg, Germany

4Division of Neurointensive Care Medicine, Department of Neurology, Beth Israel Deaconess Medical Center, USA

*Corresponding Author:
Khalid A Hanafy
Instructor of Neurology, Harvard Medical School
Division of Neurointensive Care Medicine
Department of Neurology, Beth Israel Deaconess Medical Center
3 Blackfan Circle, Boston, MA 02215, USA
Tel: 617-735-2836
Fax: 617-735-2826
E-mail: [email protected]

Received Date: February 03, 2014; Accepted Date: February 28, 2014; Published Date: March 03, 2014

Citation: Schallner N, LeBlanc R, Otterbein LE, Hanafy KA (2014) Circadian Rhythm in Stroke – The Influence of Our Internal Cellular Clock on Cerebrovascular Events. J Clin Exp Pathol 4:163. doi: 10.4172/2161-0681.1000163

Copyright: © 2014 Schallner N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The distinct temporal pattern of stroke occurrence in humans has been recognized for decades; yet, the reason underlying the temporal nature of stroke is not completely understood. Several exogenous factors such as seasonal variation, physical activity, diet and sleep/wake cycles can influence stroke occurrence. Furthermore, it has been increasingly recognized that there are several endogenous physiological functions such as blood pressure, autonomic nervous system activity, and coagulation that show temporal variance and ultimately influence susceptibility to stroke. It was long believed that the neurons within the Suprachiasmatic Nucleus (SCN) controlled all of the body’s circadian rhythm cycles serving as the “master clock”. However, circadian gene expression is inherent to almost every cell in the body, controlling cellular metabolism, and ultimately an organ’s susceptibility to injury. These new insights into the molecular mechanisms regulating circadian rhythmicity might help to explain the phenomenon of circadian variation in stroke occurrence.


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