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Clinical Outcomes in Metastatic Melanoma Patients Treated with Pembrolizumab: A Single-Center Retrospective Cohort Study | OMICS International| Abstract

Journal of Oncology Research and Treatment
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  • Research Article   
  • J Oncol Res Treat,
  • DOI: 10.4172/aot.s4.1000001

Clinical Outcomes in Metastatic Melanoma Patients Treated with Pembrolizumab: A Single-Center Retrospective Cohort Study

Sarah Mansouri1, Stéphanie Marcil2, Jean-Philippe Dulude2, Jonathan Noujaim Liu3, Guy Leblanc2 and Mai Kim Gervais2*
1Department of Medicine, Université de Montréal, Montréal, Québec, Canada
2Division of Surgical Oncology, Hospital, Université de Montréal , Montréal, Quebec, Canada
3Division of Medical Oncology, Maisonneuve-Rosemont Hospital, Université de Montréal, Montréal, Quebec, Canada
*Corresponding Author : Mai Kim Gervais, Division of Surgical Oncology, Maisonneuve-Rosemont Hospital, Université De Montré Al, Montré Al, Quebec, Canada, Tel: 514-442-4130;, Fax: 514-252-3867, Email: [email protected]

Received Date: Aug 05, 2021 / Accepted Date: Aug 19, 2021 / Published Date: Aug 26, 2021

Abstract

Objectives: The aim of this study is to review the response rate and survival outcomes of patients with stage IV melanoma treated with pembrolizumab in our center.

Methods: Patients with pathologically confirmed metastatic melanoma referred to our center from 2015 to 2017 and treated with pembrolizumab were included in this study. Follow-up consisted of clinical evaluation and FDGPET scans every 3-months. The primary outcome was the response rate of pembrolizumab. Secondary outcomes included Overall Survival (OS), Progression-Free Survival (PFS), and adverse events of pembrolizumab. Long term outcomes of patients attaining complete response for which pembrolizumab was discontinued were also analyzed. Kaplan-Meier and log-rank tests were used to calculate OS and PFS.

Results: A total of 23 patients were included in the study; 7 patients had a BRAF mutation, 16 patients received The median number of pembrolizumab cycles to achieve a Complete Response (CR) was 11 cycles. Median OS and PFS were 60 months and 28 months, respectively, with a median follow-up of 27 months. At the time of data collection, 16 patients were alive and 11 of them disease free. Grade 3 and 4 adverse events occurred in less than 13% of the patients. There were no reported pembrolizumab adverse events leading to death.

Conclusion: Our results confirmed the previously reported high response rates and complete responses of pembrolizumab in patients with metastatic melanoma. Patients with CR in whom treatment was discontinued remained disease-free for the duration of our follow-up.

Keywords: Melanoma; Metastatic; Pembrolizumab; Anti-PD1

Citation: Mansouri S, Marcil S, Dulude JP, Noujaim J, Leblanc G, et al (2021) Clincal Outcomes in Metastatic Melanoma Patients Treated with Pembrolizumab: A Single- Center Retrospective Cohort Study. J Oncol Res Treat S4: 001. Doi: 10.4172/aot.s4.1000001

Copyright: © 2021 Mansouri S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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