Abstract

The cytoskeleton, comprising actin, microtubules, and intermediate filaments, plays multifaceted roles beyond structural support. It is critical for cell migration, division, and mechanotransduction, sensing and responding to mechanical stimuli. Dynamic remodeling of these components influences cell polarity, transport, and signaling pathways. Dysregulation of cytoskeletal proteins and dynamics contributes to various diseases, including cancer and neurodegenerative disorders, highlighting their therapeutic potential. Understanding these intricate molecular mechanisms is vital for advancing cellular biology and developing novel disease interventions.