Abstract

This collection presents cryo-EM and X-ray crystallography studies revealing the structural bases of diverse biological processes. Key findings include STING activation by bacterial signals, BAM complex-mediated protein folding, CRISPR-Cas system mechanisms, and biased agonism in GPCRs. Additionally, structures explain LUBAC activation, voltage-gated sodium channel function, Factor XIa inhibition, and human rhinovirus C entry. Fundamental mitochondrial processes, like protein import and translation initiation, are also illuminated. These insights are crucial for understanding cellular health, disease pathogenesis, and inform the rational design of therapeutics and biotechnological tools.