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Deficient of Megalin in Stable Renal Transplanted Patients with Proximal Tubular Dysfunction | OMICS International| Abstract
ISSN: 2475-7640

Journal of Clinical and Experimental Transplantation
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  • Research Article   
  • J Clin Exp Transplant 2016, Vol 1(1): 107
  • DOI: 10.4172/2475-7640.1000107

Deficient of Megalin in Stable Renal Transplanted Patients with Proximal Tubular Dysfunction

Ana Cristina Carvalho De Matos1*, Niels Olsen Saraiva Câmara2,4, Alexandre Maurano5, Marcelino Durão1,2, Eduardo José Tonato1, Lucio Roberto Requião-Moura1, Marcus Vinicius Corpa6, Marcello Fabiano Franco7, Luiz Antonio Ribeiro Moura7 and Alvaro Pacheco-Silva1,2
1Renal Transplantation Unit, Hospital Israelita Albert Einstein, , São Paulo, Brazil
2Division of Nephrology, Universidade Federal de São Paulo (UNIFESP), Hospital do Rim e Hipertensão, Federal University of Sao Paulo, Fundação Oswaldo Ramos, São Paulo, Brazil
3Department of Immunology, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), , ão Paulo, Brazil
4Renal Physiology Laboratory, Faculty of Medicine, University of São Paulo, Brazil
5Radiology Unit, Hospital Israelita Albert Einstein, , São Paulo, Brazil
6Department of Pathology, Hospital Israelita Albert Einstein, , São Paulo, Brazil
7Department of Pathology, Universidade Federal de Sao Paulo, São Paulo, Brazil
*Corresponding Author : Ana Cristina Carvalho De Matos, Transplant Department, Hospital Israelita Albert Einstein, São Paulo, Brazil, Tel: +5511 21510432, Email: [email protected]

Received Date: Jun 06, 2016 / Accepted Date: Aug 08, 2016 / Published Date: Aug 15, 2016

Abstract

Introduction: Renal-transplant patients with stable graft function and proximal tubular dysfunction (PTD) have an increased risk for IF/TA. The morphological features associated with this dysfunction are unknown. Material and methods: 54 renal transplant patients with normal and stable renal function were submitted to a biopsy and had urinary retinol binding protein (uRBP) and renal function assessment. Patients were divided according to uRBP levels: 1, these findings had no association with uRBP levels. Megalin expression was observed at BB of PTC, 13.7% of bxs presented its expression in less than 50% of tubules, 56.8% had in more than 50% of tubules but with discontinuity over the BB and in 29.5% megalin expressed in more than 50% of tubules continuouslly over the BB. Patients who presented uRBP > 0.6 mg/L had lower amount of megalin expression in their biopsies, p=0.007. Cellular RBP expression was observed diffusely over the cytoplasma of PTC, with different intensities. No correlation was found between tubular megalin expression and uRBP values with CRBP expression. Conclusions: Half of renal transplant patients with normal renal function had PTD. The deficiency of megalin expression could be the subjacent functional alteration found in patients with PTD.

Keywords: Retinol binding protein; Proximal tubular function; Kidney transplantation; Tubulointerstitial injury; Chronic allograft; Nephropathy; Allograft renal biopsy

Citation: Matos ACC, Câmara NOS, Maurano A, Durão M, Tonato EJ, et al. (2016) Deficient of Megalin in Stable Renal Transplanted Patients with Proximal Tubular Dysfunction. J Clin Exp Transplant 1: 107. Doi: 10.4172/2475-7640.1000107

Copyright: © 2016 Matos ACC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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