ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Review Article   
  • J Alzheimers Dis Parkinsonism,

Dietary Polyphenols as Potential Therapeutics in Alzheimer?s Disease: Pleiotropic Effects and Toxicity Prediction Models

Efstathia Kalli1* and Vlamos Panayiotis2
1Department of Informatics, Ionian University,7 Tsirigoni Square, Corfu, Greece
2Department of Informatics, Director of Bioinformatics and Human Electrophysiology Laboratory, Ionian University, Corfu, Greece
*Corresponding Author : Efstathia Kalli, Department of Informatics, Ionian University, 7 Tsirigoni Square, Corfu, Greece, Tel: 26610 87760, Email: c15kall@ionio.gr

Received Date: Mar 25, 2022 / Published Date: Apr 25, 2022

Abstract

Individualized nutritional treatment with polyphenols has been proposed in the early stages of Alzheimer’s disease. However, it remains unclear at what doses polyphenols and their metabolites enter the brain tissue and whether they can act at sufficient concentrations. The present review provides useful insights into the multiple modes of actions of selected polyphenols as potential therapeutic tools at the pre-clinical stage of Alzheimer’s disease, as well as their ability to cross the blood-brain barrier and their detrimental effects after high dose consumptions. Several studies proposed flavonoids for their potential value in prevention and treatment of neurodegenerative diseases. The scarcity of clinical data though highlights the need for conducting metabolomics studies and well-designed clinical trials. Prolonged clinical trials with bioinformatics tools are needed to fully elucidate both neuroprotective effects and possible risks from polyphenol consumption at concentrated high doses.

Citation: Kalli E, Panayiotis V (2022) Dietary Polyphenols as Potential Therapeutics in Alzheimer’s Disease: Pleiotropic Effects and Toxicity Prediction Models. J Alzheimers Dis Parkinsonism 12: 540.

Copyright: © 2022 Kalli E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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