Abstract

The purpose of this study is to explore the infertility activity of eugenol and Ocimum sanctum Linn. Leaf extract from reproduction of female rats, 4 months, weighing 170 ± 20 g adult female rats. Group I served as control while group II and III received Eugenol (99%) at a dose of 0.4 ml/day/rat and Ocimum sanctum Linn. Leaf extract with a dose of 500 mg/kg body weight/day/rat, orally respectively for 15 days. All reproductive parameters, such as biochemical parameters of ovary, uterus and liver, serum hormone levels, measurement of cytokine antioxidant enzymes, infertility activity. The effects of Eug and OS extracts on the concentration of sialic acid, acid phosphatase and alkaline phosphatase were also significantly reduced after the administration of Eug and OS in the ovary and uterus (P<0.05). These effects are related to the increase in serum levels of (cytokine) PGE2 and PGF2α (P<0.05) and the decrease ovarian of TNF-α, IL-1β and total peroxidase (P<0.05). The total acid phosphatase in the liver increased (P<0.05), the alkaline phosphatase content decreased (P<0.05), and there was no significant change in adenosine triphosphatase. In conclusion, it is clear that medicinal plants play an important role as an infertility agent. Ovarian weight loss after treatment may be due to reduced follicular growth and ovulation, depending on the availability of gonadotropin. There is a decrease in ovulation, therefore the antifertility activity of Eugenol and Ocimum sanctum Linn. Leaf extract in female wistar rats.

Keywords: Eugenol; Infertility; Liver; Ocimum sanctum; Ovary; Uterus