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Effect of Nutrisim on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung| Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol 2014, Vol 4(1): 153
  • DOI: 10.4172/2161-0681.1000153

Effect of Nutrisim on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung

Erika D González-Renovato1, Moisés Alatorre-Jiménez1, Oscar K Bitzer-Quintero2, Sergio Sánchez-Luna1, Luis J Flores-Alvarado3, Rolando Romero-Dávalos4, Luis Romero4, José J Hernández-Andalón4, Genaro G Ortiz1* and Fermín P Pacheco-Moisés
1División de Neurociencias, Laboratorio de Mitocondria, Estrés Oxidativo & Patología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, Mexico
2División de Neurociencias, Laboratorio de Neuroinmunomodulación Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social.Guadalajara, Jalisco, Mexico
3Departamento de Bioquímica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Guadalajara, Jalisco, Mexico
4Área de Desarrollo e Investigación Científica, Laboratorios BioSim©. Distrito Federal, Mexico
*Corresponding Author : Genaro G Ortiz, División de Neurociencias, Laboratorio de Mitocondria, Estrés Oxidativo & Patología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, CP 44340, Guadalajara, Jalisco, Mexico, Tel: +52 33 3638 5593, Email: [email protected]

Received Date: Nov 01, 2013 / Accepted Date: Nov 29, 2013 / Published Date: Dec 04, 2013

Abstract

Bacterial Lipopolysaccharide (LPS) is a glycolipid component of the cell wall of Gram-negative bacteria and is an endotoxin implicated in triggering sepsis and septic shock. Sepsis and its sequelae represent a continuum of clinical syndrome encompassing systemic inflammation, coagulopathy, abnormalities of the renal, hepatic, pulmonary, and hematologic systems followed by multi-organ failure. NutriSim©, a nutritional supplement, has previously been tested in an experimental model of septic shock; for example, a single dose of NutriSim© diminishes significantly the production of serum proinflammatory cytokines, attenuates the oxidative stress markers and preserves membrane fluidity in rat liver mitochondria. Therefore, the aim of the present study was to evaluate the protective effect of NutriSim© on survival and histological alterations in liver, kidney and lung associated with endotoxic shock induced by LPS. The results in this work showed that treatment with a single dose of NutriSim© 15 min prior or after LPS challenge, effectively protects the morphological damage in vital organs such as liver, kidney and lung, and improved the survival rate of LPS-treated rats. In conclusion, a single dose of NutriSim© in a septic shock model induced by LPS appears to effectively protect vital organ damage from morphological injury and reduces mortality.

Keywords: NutriSim©; Septic shock; Survival; Liver; Lipopolysaccharide

Citation: González-Renovato ED, Alatorre-Jiménez M, Bitzer-Quintero OK, Sánchez-Luna S, Flores-Alvarado LJ, et al. (2013) Effect of Nutrisim© on Endotoxic Shock Induced by Lipopolysaccharide from Escherichia coli: 0111:B4 in Rats: Structural Study of Liver, Kidney and Lung. J Clin Exp Pathol 4:153. Doi: 10.4172/2161-0681.1000153

Copyright: © 2013 González-Renovato ED, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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