alexa Effect of Persistent Organic Pollutants (Dioxins) on Rat Myocardium and Amelioration with Antioxidant Vitamins (Role of Aryl Hydrocarbon Receptors and Cytochrome P450)
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Persistent Organic Pollutants (Dioxins) on Rat Myocardium and Amelioration with Antioxidant Vitamins (Role of Aryl Hydrocarbon Receptors and Cytochrome P450)

Nashwa S Wahba1, Mona G Amer1,2*, Rehab A Karam3 and Rasha H Mohamed4

1Histology &Cell Biology department, Faculty of Medicine, Zagazig University, Egypt

2Taif University, Saudi Arabia

3Medical Biochemistry department, Faculty of Medicine, Zagazig University, Egypt

4Biochemistry Department, Faculty of pharmacy, Zagazig University, Egypt

*Corresponding Author:
Dr. Mona Amer
Lecturer of Histology and Cell Biology
Faculty of Medicine, Zagazig university, Egypt
Tel: 00201005057244
E-mail: mona [email protected]

Received date: September 10, 2012; Accepted date: September 24, 2012; Published date: September 26, 2012

Citation: Wahba NS, Amer MG, Karam RA, Mohamed RH (2012) Effect of Persistent Organic Pollutants (Dioxins) on Rat Myocardium and Amelioration with Antioxidant Vitamins (Role of Aryl Hydrocarbon Receptors and Cytochrome P450). J Clin Exp Pathol 2:130. doi:10.4172/2161-0681.1000130

Copyright: © 2012 Wahba NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Epidemiologic studies have linked dioxins exposure to ischemic heart disease induced mortality. This study aimed
to investigate the effect of subchronic combined exposure to tetra chloro dibenzodioxin (TCDD) and dibenzofuran (DF)
on left ventricular myocardium of male rats; and the possible underlying mechanism. Moreover, this work aimed to
determine the ameliorative effect of antioxidant vitamins (A, E) supplementation. Fifty animals were classified into four
groups: control group (I); group (II) received vitamins only; group (III) included twenty animals received a dose of 1/10
of LD50 of combined TCDD/DF and group (IV) was included ten animals that received vitamins A and E in combination
with TCDD/DF. Left ventricular myocardium was examined using histological study, immunohistochemical detection of
Aryl Hydrocarbon Receptors (AHR) and mRNA expression of cytochrome P450 gene. Also, oxidant antioxidant markers
in tissue homogenate were detected. Progressive cardiomyopathy, myocardial necrosis, interstitial and perivascular
fibrosis were evident in a time related manner after dioxins treatment. This was associated with increased immunohistochemical
expression of AHR and mRNA expression of CYP1A1. Oxidative stress was evident in left ventricle of
dioxins treated group. These results suggested that combined TCDD/DF exposure has a potent cardio toxic effect
which could be ameliorated by simultaneous supplementation with vitamins A and E.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version