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Effects of Alcohol Intoxication on Response Conflict in a Flanker Task | OMICS International| Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
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  • Research Article   
  • J Addict Res Ther 2012, Vol 3(1): 002

Effects of Alcohol Intoxication on Response Conflict in a Flanker Task

Ksenija Marinkovic1*, Elizabeth Rickenbacher2 and Sheeva Azma3
1Department of Radiology, The University of California Davis, San Diego, CA, USA
2Champalimaud Foundation Neuroscience Programme at Instituto Gulbenkian de Ciencia, , Oeiras, Portugal
3Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA
*Corresponding Author : Ksenija Marinkovic, Department of Radiology, University of California, San Diego 9500 Gilman Dr. 0841, La Jolla CA 92093- 0841, USA, Tel: 858 246-0575, Fax: 858 534-1078, Email: [email protected]

Received Date: Nov 23, 2011 / Accepted Date: Feb 06, 2012 / Published Date: Feb 11, 2012


Events evoke seamlessly integrated stimulus evaluation and response preparation processing streams, guided by regulative functions that change behavior flexibly in accord with the internal goals and contextual demands. The neural basis of the effects of alcohol intoxication on these processing streams is poorly understood, despite the evidence of alcohol’s deleterious effects on both attention and motor control. In an attempt to separate and examine relative susceptibility of these two dimensions, we employed a color version of the Eriksen flanker task that manipulated compatibility at the stimulus- and response-processing levels. Functional magnetic resonance imaging (fMRI) was performed in healthy social drinkers as they participated in both alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. Alcohol increased reaction times to response-level incongruity and decreased accuracy overall. Relative to the no-conflict condition, the observed brain activity was predominantly evoked by response-related conflict in medial prefrontal and lateral prefrontal cortices under placebo, in agreement with extensive evidence of their role in conflict processing. Activity evoked by response incongruity in the medial frontal cortex and insula was insignificant under alcohol, indicating its interference with response inhibition and preparation. Conversely, activity in ventrolateral prefrontal and premotor areas was relatively greater under alcohol than placebo, suggesting their compensatory engagement. This finding is consistent with the compensatory prefrontal activity increase found in studies with chronic alcoholic individuals, indicating functional reorganization with a goal of optimizing response strategy. These results delineate functional differences and selective susceptibility of a prefrontal network subserving response-level conflict processing. Our findings are incompatible with notions that moderate alcohol primarily affects attentional or stimulus-related processing and argue instead that its primary influence is on response inhibition, selection, and execution, with ramifications for the models of behavioral self-control and the inability to refrain from drinking.

Keywords: Eriksen flanker; Anterior cingulated; Lateral prefrontal cortex; Compensatory activity

Citation: Marinkovic K, Rickenbacher E, Azma S (2012) Effects of Alcohol Intoxication on Response Conflict in a Flanker Task. J Addict Res Ther S3: 002.

Copyright: © 2012 Marinkovic K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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