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  • Research Article   
  • Sports Nutr Ther 2017, Vol 2(3): 126
  • DOI: 10.4172/2473-6449.1000126

Effects of Resistance Training Accompanied by Sustanon Abuse on Hepatotoxicity in Rats with and without Training Experience

Siavash Rahmati1, Hamid Arazi1* and Hosein Ghafoori2
1Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran
2Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran
*Corresponding Author : Hamid Arazi Ph. D, Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, P.O. Box: 41635-1438, Rasht, Iran, Tel: +98 911-1399207, Email: hamidarazi@yahoo.com

Received Date: Aug 03, 2017 / Accepted Date: Aug 21, 2017 / Published Date: Aug 31, 2017

Abstract

Objectives: Abuse of anabolic androgenic steroids (AAS) has increased. Previous studies have shown that resistance training (RT) is the main exercise modality practiced by AAS abusers and people often use them in different training situations. Thus propose of this study was to evaluate the hepatotoxic effects of sustanon (Su) as an example of anabolic androgenic steroids in male rats with and without RT experience.
Methods: Rats were divided into seven groups: control; Su - untreated sedentary rats (non-Su/ Sed); Su - treated sedentary rats (Su/Sed); Su - untreated trained rats (non-Su/Tr); Su - treated trained rats (Su/Tr); Su - untreated experience trained rats (non-Su/XTr); Su - treated experience trained rats (Su/XTr). Su - treated groups received sustanon 10 mg/kg intramuscularly once a week for 8 weeks. In the Tr and XTr groups, the animals climbed a 1.1 m vertical ladder, 3 days per week for 8 and 12 week, respectively.
Results: After Su - treatment, the mean values of serum parameters related to hepatic function were within normal ranges. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) activities were higher (P<0.05) in the liver of Su treatment groups. Tr and XTr did not change any of the above parameters.
Conclusion: The present findings suggest that the injection of Su during 8 weeks, either with or without RT up-regulation of enzymatic antioxidant activities. Moreover, these data demonstrated that liver function tests do not always reflect liver abnormalities particularly at the initial stages.

Keywords: Anabolic androgenic steroids; Antioxidant; Liver

Citation: Rahmati S, Arazi H, Ghafoori H (2017) Effects of Resistance Training Accompanied by Sustanon Abuse on Hepatotoxicity in Rats with and without Training Experience. Sports Nutr Ther 2: 126. Doi: 10.4172/2473-6449.1000126

Copyright: © 2017 Rahmati S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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