Epidemiologic, Clinicopathological, Immunohistochemical and Molecular Analysis of Gastrointestinal Glomus TumorsMaria Cecilia Mengoli1, Sofia Nosseir1, Ema Mataca1, Paola Bordi2, Massimo Lupi1, Alberto Cavazza3, Giuliana Sartori4, Alessandra Bisagni3, Marcello Tiseo2* and Giulio Rossi1
- *Corresponding Author:
- Marcello Tiseo
Medical Oncology Unit
University Hospital of Parma, Italy
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E-mail: [email protected]
Received date: July 18, 2014; Accepted date: September 08, 2014; Published date: September 11, 2014
Citation: Mengoli MC, Nosseir S, Mataca E, Bordi P, Lupi M, et al. (2014) Epidemiologic, Clinicopathological, Immunohistochemical and Molecular Analysis of Gastrointestinal Glomus Tumors. J Clin Exp Pathol 4:189. doi: 10.4172/2161-0681.1000189
Copyright: © 2014 Mengoli MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Glomus tumors are uncommon lesions that may even occur in the gastrointestinal tract. We collected 6 cases of glomus tumors (5 females, 1 male) with a median age of 65.5 years (range 48-86 years) arising from stomach (5 cases) and colon. The tumor sizes varied from 1.5 to 3.5 cm (median 2.5 cm). In our Institutions, the frequency of gastrointestinal glomus tumor is 1 case/57 Gastrointestinal Stromal Tumors (GIST). Histologically and immunohistochemically gastrointestinal glomus tumors are very identical to the conventional soft tissue counterpart, expressing smooth-muscle actin and collagen IV, but not CD117, DOG1, neuroendocrine markers, S100, cytokeratins, desmin. A molecular analysis for c-KIT and PDGFRalpha and PDGFRbeta mutations was performed with negative results by direct sequencing.
Our data confirm that glomus tumors may rarely occur in gastrointestinal tract and differential diagnosis includes several epithelial and mesenchymal tumors, more commonly arising in this site. Histology is quite peculiar, but immunostains may be helpful in differential diagnosis. No mutations were detected in c-KIT and PDGFRalpha and PDGFRbeta.