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ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Research Article

Epidemiologic, Clinicopathological, Immunohistochemical and Molecular Analysis of Gastrointestinal Glomus Tumors

Maria Cecilia Mengoli1, Sofia Nosseir1, Ema Mataca1, Paola Bordi2, Massimo Lupi1, Alberto Cavazza3, Giuliana Sartori4, Alessandra Bisagni3, Marcello Tiseo2* and Giulio Rossi1

1Section of Pathologic Anatomy, Azienda Ospedaliero-Universitaria Policlinico, Italy

2Medical Oncology Unit, University Hospital of Parma, Italy

3Operative Unit of Pathology and Department of Oncology and Advanced Technologies, Arcispedale St. Maria Nuova IRCCS, Italy

4Cervical Cancer Screening Unit, Department of Oncology and Advanced Technologies, Arcispedale St. Maria Nuova IRCCS, Italy

*Corresponding Author:
Marcello Tiseo
Medical Oncology Unit
University Hospital of Parma, Italy
Tel: 39 0521 702316 Fax: 39 0521 995448
E-mail: [email protected]

Received date: July 18, 2014; Accepted date: September 08, 2014; Published date: September 11, 2014

Citation: Mengoli MC, Nosseir S, Mataca E, Bordi P, Lupi M, et al. (2014) Epidemiologic, Clinicopathological, Immunohistochemical and Molecular Analysis of Gastrointestinal Glomus Tumors. J Clin Exp Pathol 4:189. doi: 10.4172/2161-0681.1000189

Copyright: © 2014 Mengoli MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Glomus tumors are uncommon lesions that may even occur in the gastrointestinal tract. We collected 6 cases of glomus tumors (5 females, 1 male) with a median age of 65.5 years (range 48-86 years) arising from stomach (5 cases) and colon. The tumor sizes varied from 1.5 to 3.5 cm (median 2.5 cm). In our Institutions, the frequency of gastrointestinal glomus tumor is 1 case/57 Gastrointestinal Stromal Tumors (GIST). Histologically and immunohistochemically gastrointestinal glomus tumors are very identical to the conventional soft tissue counterpart, expressing smooth-muscle actin and collagen IV, but not CD117, DOG1, neuroendocrine markers, S100, cytokeratins, desmin. A molecular analysis for c-KIT and PDGFRalpha and PDGFRbeta mutations was performed with negative results by direct sequencing.

 

Our data confirm that glomus tumors may rarely occur in gastrointestinal tract and differential diagnosis includes several epithelial and mesenchymal tumors, more commonly arising in this site. Histology is quite peculiar, but immunostains may be helpful in differential diagnosis. No mutations were detected in c-KIT and PDGFRalpha and PDGFRbeta.

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