Evaluation of Cerebral Blood Flow in Dementia with Lewy Bodies by 99mTECD SPECT Imaging
Received Date: May 17, 2018 / Accepted Date: May 26, 2018 / Published Date: Jun 02, 2018
Abstract
To clarify differences between dementia with Lewy Bodies (DLB) and Alzheimer’s disease (AD) in the actual clinical setting, we studied sites of decreased cerebral blood flow (CBF) in cases of DLB and AD by 99mT-ECD-SPECT imaging using statistical parametric mapping (SPM8). In addition, the drug sensitivity was analyzed by SPM8. Twentyfive cases were classified as DLB with AD (DLB-w) and 8 cases were DLB without AD (DLB-wo). Sites of decreased CBF in the DLB-w group were observed in the posterior cingulate gyrus, bilateral parietotemporal association areas and the occipital lobe, and these sites resembled the pattern of decreased CBF associated with AD. Among the DLBwo cases, decreased CBF was observed in frontal lobe, anterior cingulate gyrus and occipital lobe. In a comparison of sites of decreased CBF prior to treatment between 15 cases in the group exhibiting drug sensitivity and 18 cases in the group not exhibiting drug sensitivity, the drug sensitivity group exhibited more prominent decreases in CBF in the frontal lobe. In summary, 78% of DLB cases were determined to be complicated with DAT based on SPECT imaging, and the pattern of decreased CBF in these cases resembled that of DAT.
Keywords: Dementia with lewy bodies; Statistical parametric mapping; Sites of decreased cerebral blood; Alzheimer disease; DLB in autopsy cases in japan; Drug sensitivity
Citation: Kanaya K, Abe S, Hanyu H (2018) Evaluation of Cerebral Blood Flow in Dementia with Lewy Bodies by 99mT-ECD SPECT Imaging. J Alzheimers Dis Parkinsonism 8: 440 Doi: 10.4172/2161-0460.1000440
Copyright: © 2018 Kanaya K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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