Abstract

Background: Spinal malignancies can present as a progression of known cancer or as a primary neoplasm. Spine is the third most common organ affected by metastatic cancer, after the lungs and the liver. One of the losses incurred is spinal cord compression that can leads to permanent neurological impairment and compromised quality of life of patients. This study intends to analyze the correlation of several pre-treatment factors on the outcome of malignancy spine disease in patients which have been treated at Soeharso Orthopedic Hospital.
Methods: We retrospectively reviewed the medical records data of all patients treated for spinal metastasis between September 2015 until November 2018 in Soeharso Orthopaedic Hospital Surakarta. We supplement the data through interviews, then we analyze the data statistically Univariate data was calculated by chi square, while bivariate data was calculated by multiple logistic regression.
Results: Patients consisted of 15 male and 23 female in the most age range at 41-60 years (mean=52 years). Patients with elevated pre-treatment serum LDH level (>280 IU) were 5.89 times more likely to develop more severe neurological deficits, while the patients with high level ALP serum (>128 IU) have a mortality rate as high as 5.81 times greater.
Conclusion: Our study suggest that, gender, age, LDH and ALP baseline serum can be used as references to predict the prognosis in spine malignancy with elevated baseline serum LDH and ALP indicates a poor prognosis.

Keywords: Alkaline phospatase; Lactate dehydrogenase; Clinical outcomes; Spine malignancy